Kodama M, Kodama T
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya.
Jpn J Cancer Res. 1988 May;79(5):608-17. doi: 10.1111/j.1349-7006.1988.tb00030.x.
The present study investigated the problem of whether the therapeutic efficacy of cyclophosphamide in the in vivo Ehrlich ascites tumor system can be improved by adjuvant use of hydrocortisone or of dietary hydrocortisone mobilizers. In the chemotherapy experiment, female ICR mice each received an inoculum of 1 x 10(6) cells of Ehrlich ascites tumor ip followed by 2 ip injections of cyclophosphamide 36 and 37 hr later (2.4 mg/mouse for the 1st injection, and 1.0 mg/mouse for the 2nd injection). The effects of both cyclophosphamide and adjuvant treatments were assessed in terms of either survival rate or cure rate in the 1-month experiment. The results obtained were as follows. 1) Prolonged use of hydrocortisone as an adjuvant can improve the survival of cyclophosphamide-treated mice. 2) Adjuvant use of a rice-rich diet for maintenance increased the rates of both survival and cure in the cyclophosphamide-treated mice. 3) The same maintenance of mice on a rice-rich diet increased transplantation immunity on the one hand, and induced a set of steroidal changes including hydrocortisone excess on the other hand. 4) Evidence is presented to indicate that the beneficial influence of a rice-rich diet on the drug effect is related to an increase of transplantation immunity in the host, and that there could be a causal relationship between hormonal and immunological changes in rice-saturated mice.
本研究探讨了在体内艾氏腹水瘤系统中，环磷酰胺的治疗效果是否可通过辅助使用氢化可的松或膳食氢化可的松动员剂得到改善。在化疗实验中，雌性ICR小鼠每只腹腔注射1×10(6)个艾氏腹水瘤细胞接种物，36和37小时后腹腔注射2次环磷酰胺（第1次注射2.4mg/小鼠，第2次注射1.0mg/小鼠）。在为期1个月的实验中，根据生存率或治愈率评估环磷酰胺及辅助治疗的效果。得到的结果如下：1）长期使用氢化可的松作为辅助剂可提高环磷酰胺治疗小鼠的生存率。2）辅助使用富含大米的饮食进行维持可提高环磷酰胺治疗小鼠的生存率和治愈率。3）小鼠维持富含大米的饮食一方面可增强移植免疫力，另一方面可诱导包括氢化可的松过量在内的一系列甾体变化。4）有证据表明，富含大米的饮食对药物效果的有益影响与宿主移植免疫力的增强有关，并且在食用大米饱和的小鼠中，激素变化与免疫变化之间可能存在因果关系。
