Borran Mina, Minaiyan Mohsen, Zolfaghari Behzad, Mahzouni Parvin
School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Avicenna J Phytomed. 2017 May-Jun;7(3):250-260.
Antioxidant, anti-inflammatory, analgesic and antimicrobial activities of () could be helpful in the treatment of acute pancreatitis; thus, this study was designed to investigate the effects of on cerulein-induced acute pancreatitis in mice.
Three doses (100, 200 and 400 mg/kg) of hydro-alcoholic extract were administered both orally (60 minutes before pancreatitis induction, p.o.) and intra-peritoneally (30 minutes before pancreatitis induction, i.p.) to different groups of mice (n=6). Pancreatitis was induced by five injections (i.p.) of cerulein 50μg/kg body weight with 1 hr intervals. Animals were euthanized 5 hr after the last injection of cerulein and tissue injures were assessed biochemically and pathologically.
extract 200 and 400mg/kg (p.o.) and extract 400 mg/kg (i.p.) reduced pancreatic tissue myeloperoxidase (MPO) activity and serum amylase and lipase levels and alleviated histological parameters.
These data suggest that hydro-alcoholic extract was effective in protecting against experimental acute pancreatitis and possibly the efficacy depends on dose and route of administration.
（提取物名称）的抗氧化、抗炎、镇痛和抗菌活性可能有助于治疗急性胰腺炎；因此，本研究旨在探讨（提取物名称）对小鼠雨蛙素诱导的急性胰腺炎的影响。
将三个剂量（100、200和400mg/kg）的（提取物名称）水醇提取物分别经口（在诱导胰腺炎前60分钟，口服）和腹腔注射（在诱导胰腺炎前30分钟，腹腔注射）给予不同组的小鼠（n=6）。通过腹腔注射5次50μg/kg体重的雨蛙素，间隔1小时，诱导胰腺炎。在最后一次注射雨蛙素后5小时对动物实施安乐死，并通过生化和病理方法评估组织损伤情况。
200和400mg/kg（经口）的（提取物名称）提取物以及400mg/kg（腹腔注射）的（提取物名称）提取物降低了胰腺组织髓过氧化物酶（MPO）活性以及血清淀粉酶和脂肪酶水平，并改善了组织学参数。
这些数据表明，（提取物名称）水醇提取物对实验性急性胰腺炎具有保护作用，其疗效可能取决于给药剂量和途径。
