Troiano Giuseppe, Dioguardi Mario, Cocco Armando, Laino Luigi, Cervino Gabriele, Cicciu Marco, Ciavarella Domenico, Lo Muzio Lorenzo
Oral Health Prev Dent. 2017;15(5):421-426. doi: 10.3290/j.ohpd.a38732.
To examine whether a difference exists in the relapse rate between the conservative and radical approaches after the treatment of solid/multicystic ameloblastoma (SMA), a systematic review of the literature based on evidence of the last decade was performed.
The search strategy incorporated examinations of electronic databases, supplemented by hand searches. A search of four electronic databases, including Ovid MEDLINE, PubMed, EMBASE and Web of Science, was carried out for relevant studies published in the English language from January 2005 to September 2015. Cross referencing and hand research was used to identify further articles. Relative Risk (RR) as effect estimates was calculated in both fixed and random effects models.
Of 4234 abstracts screened, only 26 articles met the inclusion criteria and were screened in full text. Of these, only 4 were included in the final meta-analysis.
The inverse of variance test revealed a statistical difference in the relapse rate for SMA treatment with the conservative vs radical approach. The higher recurrence rate after a conservative approach compared to the surgical approach is significant. However, this review cannot give any recommendation due to the lack of clinical evidence.
为了研究实体/多囊性成釉细胞瘤（SMA）治疗后保守治疗与根治性治疗的复发率是否存在差异，基于过去十年的证据对文献进行了系统综述。
检索策略包括电子数据库检索，并辅以手工检索。对四个电子数据库进行检索，包括Ovid MEDLINE、PubMed、EMBASE和Web of Science，以查找2005年1月至2015年9月以英文发表的相关研究。通过交叉引用和手工检索来识别更多文章。在固定效应模型和随机效应模型中均计算相对危险度（RR）作为效应估计值。
在筛选的4234篇摘要中，只有26篇文章符合纳入标准并进行了全文筛选。其中，只有4篇被纳入最终的荟萃分析。
方差倒数检验显示，SMA治疗中保守治疗与根治性治疗的复发率存在统计学差异。与手术治疗相比，保守治疗后较高的复发率具有显著性。然而，由于缺乏临床证据，本综述无法给出任何建议。
