Stenina M A, Potapova A A, Biriukov A V, Skripnik A Iu, Cheredeev A H
Biull Eksp Biol Med. 1986 Aug;102(8):215-7.
Phytohemagglutinin-stimulated lymphocyte proliferation by con A-induced immunoregulatory cells has been estimated in patients with active systemic lupus erythematosus (SLE) treated with prednisolone. Using the combination of normal immunoregulatory cells and proliferating target cells from normal donors with immunoregulatory cells and target cells from SLE patients, it was shown that the response to immunoregulatory cells in target cells of SLE patients was impaired. This is confirmed by a slight inhibition of SLE target cell proliferation and the activating effect of immunoregulatory cells on the proliferation of "sick" targets. The data give evidence of impaired T-T-cell interaction that may be a possible mechanism of immunoregulatory defects in SLE. These disturbances can, probably, cause hyperreactivity of suppressor cells affecting normal lymphocyte proliferation. It was shown that theophylline was useful for the correction of these disorders.
在接受泼尼松龙治疗的活动性系统性红斑狼疮（SLE）患者中，已对伴刀豆球蛋白A诱导的免疫调节细胞刺激的植物血凝素刺激淋巴细胞增殖进行了评估。使用来自正常供体的正常免疫调节细胞与增殖靶细胞以及来自SLE患者的免疫调节细胞与靶细胞的组合，结果显示SLE患者靶细胞中对免疫调节细胞的反应受损。SLE靶细胞增殖的轻微抑制以及免疫调节细胞对“病态”靶细胞增殖的激活作用证实了这一点。这些数据证明了T - T细胞相互作用受损，这可能是SLE免疫调节缺陷的一种可能机制。这些紊乱可能会导致抑制细胞的反应过度，从而影响正常淋巴细胞增殖。结果表明，茶碱对纠正这些紊乱是有用的。
