Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Clin Exp Dermatol. 2017 Dec;42(8):887-889. doi: 10.1111/ced.13201. Epub 2017 Jul 27.
Orofacial granulomatosis (OFG) is the term given to a group of diseases characterized by the presence of non-necrotizing granulomatous inflammation affecting the soft tissues of the orofacial region. Treatment of OFG is often challenging and unsatisfactory. We report on a 32-year-old man with a 2-year history of oedema and swelling of the upper lip without systemic symptoms. The history, clinical features and histopathological findings led to the diagnosis of cheilitis granulomatosa (CG), a disease included in the spectrum of OFG. The patient was treated with oral diaminodiphenyl sulfone (DDS) and clofazimine without success. Oral doxycycline led to a slight improvement of the disease. Because the volume of the upper lip was twice normal size, surgical reduction was performed, followed by administration of oral doxycycline for 3 months. This therapeutic approach led to complete remission, with no recurrence after 3 years.
口面部肉芽肿病（OFG）是一组以非坏死性肉芽肿性炎症为特征的疾病，影响口面区域的软组织。OFG 的治疗常常具有挑战性且效果不佳。我们报告了一例 32 岁男性，其患有 2 年的上唇肿胀和水肿，无全身症状。病史、临床特征和组织病理学发现导致诊断为肉芽肿性唇炎（CG），这是 OFG 谱中的一种疾病。该患者接受了口服二氨基二苯砜（DDS）和氯法齐明治疗，但未取得成功。口服多西环素使病情略有改善。由于上唇的体积是正常大小的两倍，因此进行了手术缩小，随后口服多西环素治疗 3 个月。这种治疗方法导致完全缓解，3 年后无复发。
