Laboratory of Pathology and Immunohistochemistry (LAPI), School of Dentistry, Universidade Federal do Pará (UFPA), Belém, PA, Brazil.
Department of Stomatology and Oral and Maxillofacial Surgery, Hospital Metropolitano Odilon Behrens (HMOB), Belo Horizonte, MG, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Jul;128(1):e1-e5. doi: 10.1016/j.oooo.2019.02.024. Epub 2019 Mar 1.
Orofacial granulomatosis (OFG) is a chronic inflammatory disease that typically affects the soft tissues of the orofacial region. The most common clinical manifestation of OFG is lip swelling, which may be associated with intrabuccal ulcerations and increased growth of the gingiva and mucosa, as well as cutaneous erythema and facial edema. The treatment for OFG is challenging, and sometimes considered unsatisfactory. Thus, this study presents a case report of OFG and the therapeutic regimen applied. A 47-year-old man presented with increased lip volume which had started 10 months earlier. His lips were thick with a fibroelastic consistency, which were painless upon palpation. Incisional biopsy and histopathological analysis of the upper lip revealed non-specific granulomatous inflammation and the diagnosis of OFG was subsequently made. Low-level laser therapy was successfully used to treat OFG in this case, and appears to be an efficient treatment for OFG when corticosteroid therapy is not enough.
口面型肉芽肿病（OFG）是一种慢性炎症性疾病，通常影响口面区域的软组织。OFG 最常见的临床表现是唇部肿胀，可能伴有口腔内溃疡和牙龈及黏膜增生，以及皮肤红斑和面部水肿。OFG 的治疗具有挑战性，有时被认为效果不佳。因此，本研究报告了一例 OFG 病例及应用的治疗方案。一名 47 岁男性因唇部体积增大就诊，该症状始于 10 个月前。他的嘴唇增厚，质地坚韧有弹性，触诊时无疼痛感。上唇的切开活检和组织病理学分析显示为非特异性肉芽肿性炎症，随后诊断为 OFG。本病例采用低水平激光治疗成功治疗了 OFG，并且在皮质类固醇治疗不足时，它似乎是治疗 OFG 的有效方法。
