Department Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
University of Groningen, University Medical Centre, Dept. Neuroscience, Groningen, The Netherlands.
Clin Pharmacol Ther. 2018 Feb;103(2):262-270. doi: 10.1002/cpt.801. Epub 2017 Aug 29.
The poor predictive quality of currently used animal models in preclinical research is an important cause of the high attrition of promising drug candidates for human autoimmune disease in clinical trials. Examples from own work in a primate multiple sclerosis (MS) model illustrate that important lessons can be learned from a critical reassessment of failed drugs in the animal model, which can help improve the animal model and better understand the targeted disease.
目前在临床前研究中使用的动物模型预测质量较差，是导致在临床试验中具有前景的治疗人类自身免疫性疾病候选药物大量淘汰的一个重要原因。从我们在灵长类多发性硬化症 (MS) 模型中的工作中举例说明，从对动物模型中失败药物的严格重新评估中可以吸取重要的经验教训，这有助于改进动物模型并更好地了解目标疾病。
