School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, 14040-903, SP, Brazil.
Curr Med Chem. 2019;26(23):4403-4434. doi: 10.2174/0929867324666170727103901.
Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to describe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazolebased molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis.
被忽视的疾病（NDs）影响着数百万人，尤其是全世界最贫困的人群。目前，几种有效的治疗方法都被证明是不够的。在这种情况下，三唑衍生物在药物化学中显示出了很大的相关性，因为它们具有广泛的生物活性。这篇综述旨在描述一些最相关和最近的研究，这些研究集中在针对四种有代表性的 NDs 的 1,2,3-和 1,2,4-三唑基分子上：恰加斯病、疟疾、结核病和利什曼病。
