Richard Y, Georget E
Cell Immunol. 1986 Aug;101(1):132-42. doi: 10.1016/0008-8749(86)90192-9.
Using PWM-driven immunoglobulin synthesis, we studied the regulatory effects of the peripheral blood T-lymphocyte subpopulations defined by the E10 antigen. This previously described antigen (E10) is present on 60% of TPBL, of T4+, and of T8+ cells. The helper activity on PWM-driven B-cell differentiation appears to be highly increased in E10- T cells. This higher capacity does not apparently reflect a different susceptibility to suppressor influences as comparable results were obtained when such suppressor influences are minimized either by removal of T8+ cells from E10- and E10+ T cells, or by removal of monocytes from responding B-cell populations. In contrast, the relative function of T-cell subsets defined by the related antigen 3A1 are influenced by the presence of suppressor cells. It is only in the presence of both T8+ cells and monocytes that 3A1+ cells exhibit a higher inducer effect. Our results suggest that E10 and 3A1 antigens--although showing strong distribution homologies--define different regulatory T-cell populations.
利用脉冲宽度调制驱动的免疫球蛋白合成，我们研究了由E10抗原定义的外周血T淋巴细胞亚群的调节作用。这种先前描述的抗原（E10）存在于60%的总外周血淋巴细胞、T4+细胞和T8+细胞上。E10-T细胞对脉冲宽度调制驱动的B细胞分化的辅助活性似乎显著增加。当通过从E10-和E10+T细胞中去除T8+细胞或从反应性B细胞群体中去除单核细胞来最小化这种抑制影响时，可获得类似结果，因此这种更高的能力显然并不反映对抑制影响的不同敏感性。相比之下，由相关抗原3A1定义的T细胞亚群的相对功能受抑制细胞的存在影响。只有在同时存在T8+细胞和单核细胞的情况下，3A1+细胞才表现出更高的诱导作用。我们的结果表明，E10和3A1抗原——尽管显示出很强的分布同源性——定义了不同的调节性T细胞群体。
