Irigoyen O, Mandich D, Bargellesi A
Cell Immunol. 1987 Jun;107(1):172-9. doi: 10.1016/0008-8749(87)90277-2.
Human T lymphocytes bearing the cell surface antigen T4 are functionally heterogeneous, exerting helper/inducer, suppressor-inducer, suppressor-effector, and cytotoxic activities. Other cell surface antigens with a more restricted expression may help separate T4+ lymphocytes into functionally distinct subsets. This report describes the regulatory functions of T4+ lymphocytes fractionated by the monoclonal antibody 5/9, which detects a cell surface antigen present on 50-60% of T4+ lymphocytes. The results indicate that both 5/9+ and 5/9- T4 subsets contain helper/inducer and suppressor-inducer cells. Suppressor-effector activity, however, is found predominantly within the 5/9+ T4 subset. The 5/9 antibody thus identifies the suppressor-effector subset of T4+ lymphocytes, although it does not distinguish between T4+ cells with or without helper/inducer and suppressor-inducer functions.
带有细胞表面抗原T4的人类T淋巴细胞在功能上是异质性的，具有辅助/诱导、抑制诱导、抑制效应和细胞毒性活性。其他表达较为受限的细胞表面抗原可能有助于将T4+淋巴细胞分离为功能不同的亚群。本报告描述了用单克隆抗体5/9分离的T4+淋巴细胞的调节功能，该抗体可检测到50%-60%的T4+淋巴细胞上存在的一种细胞表面抗原。结果表明，5/9+和5/9-T4亚群均包含辅助/诱导细胞和抑制诱导细胞。然而，抑制效应活性主要存在于5/9+T4亚群中。因此，5/9抗体识别出T4+淋巴细胞的抑制效应亚群，尽管它无法区分具有或不具有辅助/诱导和抑制诱导功能的T4+细胞。
