Xu Liangxiong, Wu Ping, Xue Jinghua, Molnar Istvan, Wei Xiaoyi
Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.
Natural Products Center, School of Natural Resources and the Environment, University of Arizona , Tucson, Arizona 85706, United States.
J Nat Prod. 2017 Aug 25;80(8):2215-2223. doi: 10.1021/acs.jnatprod.7b00066. Epub 2017 Jul 27.
Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.
从拟青霉属SC0924菌株的培养物中分离出8种新的β-间苯二酚内酯（RALs），包括腐皮镰刀菌烯醇型化合物拟青霉素N-P（1-3）和根赤壳菌素型代谢产物脱氯波乔宁I（4）、单青霉素VI（5）和VII（6）、4'-羟基单青霉素IV（7）以及4'-甲氧基单青霉素IV（8），同时还分离出9种已知的RALs（9-17）。化合物1和2具有新颖的6/11/5环系，化合物3是首个5'-酮基RAL。通过广泛的光谱分析、X射线衍射分析以及ECD光谱的理论计算确定了1-8的结构。化合物3、5和6对MCF-7、A549和HeLa细胞表现出细胞毒性，化合物5和7对荔枝霜霉病菌具有抗真菌活性。
