卡马西平和丙戊酸对杏仁核点燃大鼠脑内免疫反应性生长抑素和γ-氨基丁酸的影响。

Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdaloid-kindled rats.

作者信息

Higuchi T, Yamazaki O, Takazawa A, Kato N, Watanabe N, Minatogawa Y, Yamazaki J, Ohshima H, Nagaki S, Igarashi Y

出版信息

Eur J Pharmacol. 1986 Jun 17;125(2):169-75. doi: 10.1016/0014-2999(86)90024-5.

Abstract

Somatostatin and gamma-aminobutyric acid (GABA) concentrations were evaluated in the brain of kindled rats treated chronically with carbamazepine and valproic acid. Kindled seizures were almost completely blocked by treatment with carbamazepine, whereas the effect of valproic acid was partial, suppressing only generalized seizures. The duration of after-discharge in amygdala was suppressed by carbamazepine not by valproic acid. Carbamazepine induced a decrease in immunoreactive somatostatin concentration and an increase in GABA concentration in the temporal cortex of kindled rats. Valproic acid induced only an increase in GABA concentration. The results suggest that somatostatin may be associated with the suppression of focal seizure in amygdala and GABA may have a role in the suppression of generalized seizures.

摘要

对长期用卡马西平和丙戊酸治疗的点燃大鼠脑内生长抑素和γ-氨基丁酸（GABA）浓度进行了评估。卡马西平治疗几乎完全阻断了点燃性癫痫发作，而丙戊酸的作用是部分性的，仅抑制全身性癫痫发作。卡马西平可抑制杏仁核后放电的持续时间，而丙戊酸则不能。卡马西平可使点燃大鼠颞叶皮质中免疫反应性生长抑素浓度降低，GABA浓度升高。丙戊酸仅使GABA浓度升高。结果表明，生长抑素可能与杏仁核局灶性癫痫发作的抑制有关，而GABA可能在全身性癫痫发作的抑制中起作用。