卡马西平和卡马西平-10,11-环氧化物可抑制大鼠杏仁核点燃性癫痫发作，但不能阻止其发展。

Carbamazepine and carbamazepine-10,11-epoxide inhibit amygdala-kindled seizures in the rat but do not block their development.

作者信息

Weiss S R, Post R M

机构信息

Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892.

出版信息

Clin Neuropharmacol. 1987 Jun;10(3):272-9. doi: 10.1097/00002826-198706000-00008.

DOI:10.1097/00002826-198706000-00008

PMID:3454717

Abstract

The effect of carbamazepine and its -10,11-epoxide on the development of amygdala-kindled seizures and on completed kindled seizures in the rat was evaluated. Neither carbamazepine (15 mg/kg) nor the -10,11-epoxide (15 mg/kg) was capable of preventing the development of amygdala-kindled seizures, although both drugs, at these doses, exerted marked anticonvulsant effects on completed kindled seizures. These data suggest that different phases of kindling are differentially responsive to pharmacological intervention. They also support the conclusion that different mechanisms underlie the acquisition and maintenance of kindled seizures.

摘要

评估了卡马西平及其-10,11-环氧化物对大鼠杏仁核点燃癫痫发作的发展以及完全点燃癫痫发作的影响。卡马西平（15毫克/千克）和-10,11-环氧化物（15毫克/千克）均不能预防杏仁核点燃癫痫发作的发展，尽管这两种药物在这些剂量下对完全点燃的癫痫发作均有显著的抗惊厥作用。这些数据表明，点燃的不同阶段对药物干预的反应不同。它们还支持这样的结论，即点燃癫痫发作的获得和维持有不同的机制。