Hall M A, Beech R C, Seal D V
J Hosp Infect. 1986 Jul;8(1):57-63. doi: 10.1016/0195-6701(86)90105-2.
In 1982, the antibiotic treatment policy for suspected sepsis in neonates admitted to the Southampton special care baby unit was changed from intravenous gentamicin plus penicillin to intravenous cefotaxime with or without penicillin. Analysis of blood culture results during the first 2 years following the change indicates that a higher proportion of blood culture isolates showed sensitivity to cefotaxime compared with gentamicin. Only one baby died with proven bacterial sepsis and this was not thought to be due to treatment failure. Our data suggest that, on our unit, cefotaxime is a suitable alternative to the aminoglycosides for the management of suspected sepsis in the newborn.
1982年，南安普顿特别护理婴儿病房收治的疑似败血症新生儿的抗生素治疗方案从静脉注射庆大霉素加青霉素改为静脉注射头孢噻肟，可加用或不加用青霉素。对方案改变后的头两年血培养结果的分析表明，与庆大霉素相比，血培养分离出的菌株中对头孢噻肟敏感的比例更高。只有一名确诊为细菌性败血症的婴儿死亡，且这一情况不被认为是治疗失败所致。我们的数据表明，在我们的病房，头孢噻肟是新生儿疑似败血症治疗中氨基糖苷类药物的合适替代药物。
