Brodski-Guerniero Alla, Paasch Georg-Friedrich, Wollstadt Patricia, Özdemir Ipek, Lizier Joseph T, Wibral Michael
MEG Unit, Brain Imaging Center, J.W. Goethe University, 60323 Frankfurt am Main, Germany, and.
Complex Systems Research Group and Centre for Complex Systems, Faculty of Engineering & IT, The University of Sydney, New South Wales 2006, Australia.
J Neurosci. 2017 Aug 23;37(34):8273-8283. doi: 10.1523/JNEUROSCI.0614-17.2017. Epub 2017 Jul 27.
Predictive coding suggests that the brain infers the causes of its sensations by combining sensory evidence with internal predictions based on available prior knowledge. However, the neurophysiological correlates of (pre)activated prior knowledge serving these predictions are still unknown. Based on the idea that such preactivated prior knowledge must be maintained until needed, we measured the amount of maintained information in neural signals via the active information storage (AIS) measure. AIS was calculated on whole-brain beamformer-reconstructed source time courses from MEG recordings of 52 human subjects during the baseline of a Mooney face/house detection task. Preactivation of prior knowledge for faces showed as α-band-related and β-band-related AIS increases in content-specific areas; these AIS increases were behaviorally relevant in the brain's fusiform face area. Further, AIS allowed decoding of the cued category on a trial-by-trial basis. Our results support accounts indicating that activated prior knowledge and the corresponding predictions are signaled in low-frequency activity (<30 Hz). Our perception is not only determined by the information our eyes/retina and other sensory organs receive from the outside world, but strongly depends also on information already present in our brains, such as prior knowledge about specific situations or objects. A currently popular theory in neuroscience, predictive coding theory, suggests that this prior knowledge is used by the brain to form internal predictions about upcoming sensory information. However, neurophysiological evidence for this hypothesis is rare, mostly because this kind of evidence requires strong a priori assumptions about the specific predictions the brain makes and the brain areas involved. Using a novel, assumption-free approach, we find that face-related prior knowledge and the derived predictions are represented in low-frequency brain activity.
预测编码表明,大脑通过将感官证据与基于现有先验知识的内部预测相结合来推断其感觉的原因。然而,为这些预测服务的(预)激活先验知识的神经生理学相关性仍然未知。基于这种预激活的先验知识必须在需要之前保持的观点,我们通过主动信息存储(AIS)测量来测量神经信号中保持的信息量。AIS是根据52名人类受试者在穆尼脸/房子检测任务基线期间的MEG记录,在全脑波束形成器重建的源时间历程上计算得出的。对面部先验知识的预激活表现为特定内容区域中与α波段相关和与β波段相关的AIS增加;这些AIS增加在大脑的梭状脸区域与行为相关。此外,AIS允许逐次试验解码提示的类别。我们的结果支持这样的观点,即激活的先验知识和相应的预测在低频活动(<30Hz)中发出信号。我们的感知不仅取决于我们的眼睛/视网膜和其他感觉器官从外界接收到的信息,还强烈依赖于我们大脑中已经存在的信息,例如关于特定情况或物体的先验知识。神经科学中目前流行的一种理论,预测编码理论,表明大脑利用这种先验知识对即将到来的感官信息形成内部预测。然而,这一假设的神经生理学证据很少,主要是因为这种证据需要对大脑做出的特定预测和涉及的脑区有很强的先验假设。使用一种新颖的、无假设的方法,我们发现与面部相关的先验知识和派生的预测在低频脑活动中得到体现。
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