Haggarty Connor, Molla Hanna, Glazer James, Tare Ilaria, Rains Alex, de Wit Harriet, Lee Royce
Biological Sciences Division, Psychiatry and Behavioral Neuroscience, University of Chicago, Detroit, IL, USA.
Pharmacy Practice, Wayne State University, Detroit, MI, USA.
Psychedelic Med (New Rochelle). 2024 Dec 2;2(4):210-220. doi: 10.1089/psymed.2024.0005. eCollection 2024 Dec.
Despite widespread popular interest in the use of low doses of Lysergic acid diethylamide (LSD) to improve mood, little is known about how these doses affect emotional processing in the brain. In this study, we tested the effect of a single low dose of LSD (26 µg) compared with placebo on electroencephalogram (EEG) event-related potentials (ERP: N170, P300 and Mismatch Negativity) in healthy adults, while participants viewed angry, happy, and neutral faces. We hypothesized that the drug might affect either neutral faces, which are sometimes perceived as threatening, or emotional faces.
Healthy young adults ( = 39) received LSD (26 µg or placebo sublingually) before completing an oddball task with emotional facial expressions during EEG recording. The N170 and P300 evoked potentials were recorded using EEG. LSD and placebo were administered in double-blind, randomized order separated by at least 7 days. During the oddball task, three emotional faces were presented infrequently (angry, happy, neutral) in a block design, and a cartoon face was presented frequently.
LSD significantly reduced the amplitude of the occipitotemporal N170 ERP to Neutral faces, but not angry or happy faces. LSD also reduced the amplitude of the midline posterior parietal P300 ERP to neutral and happy faces, but not angry faces.
These differential effects of LSD on the amplitude of the N170 and P300 to neutral and emotional faces add to our understanding of how low doses of LSD might affect the brain response to social and emotional information.
尽管人们普遍对使用低剂量麦角酸二乙酰胺（LSD）来改善情绪很感兴趣，但对于这些剂量如何影响大脑中的情绪处理却知之甚少。在本研究中，我们测试了单次低剂量LSD（26微克）与安慰剂相比，对健康成年人在观看愤怒、快乐和中性面孔时脑电图（EEG）事件相关电位（ERP：N170、P300和失配负波）的影响。我们假设该药物可能会影响有时被视为具有威胁性的中性面孔，或者影响情绪面孔。
健康的年轻成年人（n = 39）在EEG记录期间完成一项带有情绪面部表情的oddball任务之前，舌下接受LSD（26微克）或安慰剂。使用EEG记录N170和P300诱发电位。LSD和安慰剂以双盲、随机顺序给药，间隔至少7天。在oddball任务期间，以区组设计不频繁地呈现三种情绪面孔（愤怒、快乐、中性），并频繁呈现一张卡通面孔。
LSD显著降低了枕颞区对中性面孔的N170 ERP波幅，但对愤怒或快乐面孔没有影响。LSD还降低了中线顶叶后部对中性和快乐面孔的P300 ERP波幅，但对愤怒面孔没有影响。
LSD对中性和情绪面孔的N170和P300波幅的这些差异效应，增进了我们对低剂量LSD如何影响大脑对社会和情绪信息反应的理解。
