Touitou Elka, Natsheh Hiba
The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, P.O. Box 12065, Jerusalem 9112102, Israel.
Pharmaceutics. 2024 Feb 13;16(2):267. doi: 10.3390/pharmaceutics16020267.
This review focuses on nanovesicular carriers for enhanced delivery of molecules into and across the skin, from their design to recent emerging technologies. During the last four decades, several approaches have been used aiming to design new nanovesicles, some of them by altering the properties of the classic phospholipid vesicle, the liposome. Phospholipid nanovesicular systems, including the phospholipid soft vesicles as well as the non-phospholipid vesicular carries, are reviewed. The altered nanovesicles have served in the manufacture of various cosmetic products and have been investigated and used for the treatment of a wide variety of skin conditions. The evolution and recent advances of these nanovesicular technologies are highlighted in this review.
本综述聚焦于纳米囊泡载体，从其设计到最新的新兴技术，旨在增强分子进入皮肤并穿透皮肤的递送能力。在过去的四十年里，人们采用了多种方法来设计新型纳米囊泡，其中一些方法是通过改变经典磷脂囊泡（脂质体）的性质。本文综述了磷脂纳米囊泡系统，包括磷脂软囊泡以及非磷脂囊泡载体。这些经过改良的纳米囊泡已用于制造各种化妆品，并已被研究用于治疗多种皮肤疾病。本综述重点介绍了这些纳米囊泡技术的发展历程和最新进展。
