Gilbeau P M, Hosobuchi Y, Lee N M
J Pharmacol Exp Ther. 1986 Sep;238(3):974-7.
The role of dynorphin-(1-13) and dynorphin-(1-10)-amide in the neuroendocrine control of primate anterior pituitary hormones was studied in nonrestrained, ovariectomized rhesus monkeys. The effects of these opioids on plasma concentrations of prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyrotropin (TSH), and interactions with naloxone are reported here. Intravenous administration of dynorphin-(1-13), 30 to 120 micrograms/kg, significantly increased plasma PRL levels 3- to 4-fold. These PRL increases occurred within 5 min and levels remained elevated for at least 60 min. Administration of naloxone (1.0 mg/kg i.v.) antagonized the rise in PRL levels. Dynorphin-(1-13) had no significant effect on plasma LH, FSH or TSH levels. Dynorphin-(1-10)-amide (30-120 micrograms/kg) increased plasma PRL levels 2- to 4-fold at 5 to 40 min after administration. Plasma LH levels were significantly depressed 100 to 120 min postdrug. Dynorphin-(1-10)-amide produced no change in plasma FSH or TSH levels. These results indicate that dynorphin is involved in the modulation of PRL and perhaps LH secretion, although not affecting TSH or FSH release.
在未受限制的去卵巢恒河猴中，研究了强啡肽-（1-13）和强啡肽-（1-10）-酰胺在灵长类动物垂体前叶激素神经内分泌控制中的作用。本文报道了这些阿片类物质对催乳素（PRL）、促黄体生成素（LH）、促卵泡激素（FSH）和促甲状腺激素（TSH）血浆浓度的影响，以及与纳洛酮的相互作用。静脉注射30至120微克/千克的强啡肽-（1-13）可使血浆PRL水平显著升高3至4倍。这些PRL升高在5分钟内出现，且水平至少持续升高60分钟。静脉注射纳洛酮（1.0毫克/千克）可拮抗PRL水平的升高。强啡肽-（1-13）对血浆LH、FSH或TSH水平无显著影响。强啡肽-（1-10）-酰胺（30至120微克/千克）在给药后5至40分钟可使血浆PRL水平升高2至4倍。给药后100至120分钟，血浆LH水平显著降低。强啡肽-（1-10）-酰胺对血浆FSH或TSH水平无影响。这些结果表明，强啡肽参与了PRL的调节，可能还参与了LH的分泌调节，尽管不影响TSH或FSH的释放。
