Gilbeau P M, Hosobuchi Y, Lee N M
Neuroendocrinology. 1987 Apr;45(4):284-9. doi: 10.1159/000124742.
This study examines the role of dynorphin-A(1-13) and dynorphin-A(1-10)-amide in the neuroendocrine regulation of anterior pituitary hormones in nonrestrained, adult male rhesus monkeys. The effects of these opioids on plasma concentrations of prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyrotropin (TSH) and growth hormone (GH) were assessed. Intravenous administration of dynorphin-A(1-13), 1-120 micrograms/kg, significantly increased plasma PRL levels. Average maximal increases of 90-230% occurred within 5 min and levels remained significantly elevated for up to 120 min. PRL response reached a plateau following the 30 micrograms/kg dose. Dynorphin-A(1-13) had no observable effects on plasma concentrations of LH, FSH, TSH or GH at any dose level studied. Administration of dynorphin-A(1-10)-amide produced significant dose-dependent increases in plasma PRL concentrations. Dose levels of 1-120 micrograms/kg produced mean peak increases from 100 to 230%, 5-10 min postadministration. Dynorphin-A(1-10)-amide had no significant effect on plasma concentrations of LH, FSH, TSH or GH. The increases in plasma PRL concentrations induced by dynorphin-A were naloxone-reversible. These results indicate a selective effect of dynorphin-A on the regulatory mechanisms of PRL secretion over that of other anterior pituitary hormones.
本研究考察了强啡肽A（1-13）和强啡肽A（1-10）酰胺在成年雄性恒河猴非束缚状态下对垂体前叶激素神经内分泌调节中的作用。评估了这些阿片类物质对催乳素（PRL）、促黄体生成素（LH）、促卵泡激素（FSH）、促甲状腺激素（TSH）和生长激素（GH）血浆浓度的影响。静脉注射1-120微克/千克的强啡肽A（1-13）可显著提高血浆PRL水平。在5分钟内平均最大增幅为90%-230%，且在长达120分钟内水平仍显著升高。30微克/千克剂量后PRL反应达到平台期。在所研究的任何剂量水平下，强啡肽A（1-13）对LH、FSH、TSH或GH的血浆浓度均无明显影响。注射强啡肽A（1-10）酰胺可使血浆PRL浓度产生显著的剂量依赖性升高。1-120微克/千克的剂量在给药后5-10分钟产生的平均峰值增幅为100%-230%。强啡肽A（1-10）酰胺对LH、FSH、TSH或GH的血浆浓度无显著影响。强啡肽A诱导的血浆PRL浓度升高可被纳洛酮逆转。这些结果表明，强啡肽A对PRL分泌调节机制的作用具有选择性，相对于其他垂体前叶激素而言。
