Allam-Nandyala Pushpa, Bui Marilyn M, Caracciolo Jamie T, Hakam Ardeshir
Department of Graduate Medical Education, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Int J Clin Exp Pathol. 2010 Jan 10;3(3):313-8.
A rare case of multiple malignant tumors (poorly differentiated squamous cell carcinoma and high grade osteosarcoma) arising in an ovarian dermoid cyst of a 55 year old female is reported. To the best of our knowledge, this is the first well documented example of such an unusual combination of tumors arising in a dermoid cyst. The osteosarcoma and squamous cell carcinoma appear to arise in the background of benign teratomatous environment of a dermoid cyst rather than from "pure" mixed mesodermal tumors of the ovary. The tumors did not appear to have well demarcated boundaries with a junction or close intermingling of both cell types, features less favorable for collision tumor or carcinosarcoma. Despite extensive surgery with negative surgical margins and combination chemotherapy, the patient had recurrence of the tumor within four months and she died secondary to septicemia to chemotherapy and bilateral pulmonary emboli shortly after.
报道了一例罕见的发生于一名55岁女性卵巢皮样囊肿的多发性恶性肿瘤（低分化鳞状细胞癌和高级别骨肉瘤）。据我们所知，这是首例有充分记录的在皮样囊肿中出现这种不寻常肿瘤组合的病例。骨肉瘤和鳞状细胞癌似乎是在皮样囊肿的良性畸胎瘤环境背景中发生，而非来自卵巢的“纯”混合性中胚层肿瘤。肿瘤似乎没有清晰的边界，两种细胞类型有交界处或紧密交织，这些特征不太支持碰撞瘤或癌肉瘤。尽管进行了广泛手术，手术切缘阴性并联合化疗，但患者在四个月内肿瘤复发，不久后因化疗引起的败血症和双侧肺栓塞继发死亡。
