血管生成素样蛋白 4 在禁食期间将膳食脂肪从脂肪组织中摄取走。
Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting.
机构信息
Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United States.
Department of Pharmacology and Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United States.
出版信息
Mol Metab. 2017 Jun 19;6(8):809-818. doi: 10.1016/j.molmet.2017.06.007. eCollection 2017 Aug.
OBJECTIVE
Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the kinetics of induction and tested the hypothesis that ANGPTL4 functions physiologically to reduce triglyceride delivery to adipose tissue during nutrient deprivation.
METHODS
Gene expression, LPL activity, and triglyceride uptake were examined in fasted and fed wild-type and mice.
RESULTS
was strongly induced early in fasting, and this induction was suppressed in mice with access to food during the light cycle. Fasted mice manifested increased LPL activity and triglyceride uptake in adipose tissue compared to wild-type mice.
CONCLUSIONS
is induced early in fasting to divert uptake of fatty acids and triglycerides away from adipose tissues.
目的
血管生成素样蛋白 4（ANGPTL4）是一种饥饿诱导的脂蛋白脂肪酶（LPL）抑制剂，也是调节血浆甘油三酯代谢的调节剂。在这里，我们研究了其诱导的动力学，并提出了一个假设，即 ANGPTL4 在生理上的作用是在营养缺乏时减少甘油三酯向脂肪组织的输送。
方法
检测了禁食和进食野生型和 小鼠的基因表达、LPL 活性和甘油三酯摄取情况。
结果
在禁食早期，ANGPTL4 被强烈诱导，而在光照周期中进食的 小鼠中，这种诱导被抑制。与野生型小鼠相比，禁食的 小鼠在脂肪组织中表现出更高的 LPL 活性和甘油三酯摄取。
结论
ANGPTL4 在禁食早期被诱导，以将脂肪酸和甘油三酯的摄取从脂肪组织中转移开。
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