大鼠颈上神经节中的递质与调质。

Transmitters and modulators in the superior cervical ganglion of the rat.

作者信息

Eränkö L, Päivärinta H, Soinila S, Häppölä O

出版信息

Med Biol. 1986;64(2-3):75-83.

Abstract

Several transmitters and modulators have been found to exist in the superior cervical ganglion of the rat. It has been shown that noradrenaline is present in the principal neurons and dopamine is the main catecholamine in the small intensely fluorescent cells. 5-hydroxytryptamine and histamine have been investigated immunohistochemically and found to be present only in the small intensely fluorescent cells of an adult rat, in the same cells which are also immunoreactive to tyrosine hydroxylase. On the other hand, enkephalins which were studied using highly specific antibodies against methionine-enkephalin-arginine-phenylalanine and methionine-enkephalin-arginine-glycine-leucine were found in the principal neurons and nerve fibres. Ligation studies showed that enkephalins in the superior cervical ganglion of the rat are both of intrinsic and extrinsic origin. It is evident that the transmission in the sympathetic ganglion is complex. The possible function of the transmitter and modulator candidates is discussed.

摘要

已发现大鼠颈上神经节中存在多种递质和调质。研究表明，去甲肾上腺素存在于主要神经元中，多巴胺是小而强荧光细胞中的主要儿茶酚胺。已通过免疫组织化学方法对5-羟色胺和组胺进行了研究，发现它们仅存在于成年大鼠的小而强荧光细胞中，这些细胞对酪氨酸羟化酶也具有免疫反应性。另一方面，使用针对甲硫氨酸脑啡肽-精氨酸-苯丙氨酸和甲硫氨酸脑啡肽-精氨酸-甘氨酸-亮氨酸的高特异性抗体研究发现，脑啡肽存在于主要神经元和神经纤维中。结扎研究表明，大鼠颈上神经节中的脑啡肽既有内源性起源，也有外源性起源。显然，交感神经节中的传递是复杂的。文中讨论了候选递质和调质的可能功能。