Roelants J A, Vermeulen M J, Koning I V, Groenenberg I A L, Willemsen S P, Hokken-Koelega A C S, Joosten K F M, Reiss I K M, Steegers-Theunissen R P M
Department of Pediatrics, Subdivision of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Department of Obstetrics and Gynaecology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Pediatr Obes. 2017 Aug;12 Suppl 1:65-71. doi: 10.1111/ijpo.12231. Epub 2017 Jul 28.
The predisposition for obesity is suggested to originate in the prenatal period. Prenatal markers are needed to identify foetuses at risk for neonatal adiposity, as early marker of childhood obesity.
The aim of this study is to assess the association between foetal fractional thigh volume (TVol) and neonatal percentage fat mass from mid-gestation onward.
In this perinatal cohort study, singleton pregnancies with term born infants were included. Foetal TVol was measured on three-dimensional ultrasound scans (3D US) obtained at 22, 26 and 32 weeks of gestation. Neonatal body composition measurement (percentage body fat (%BF)) was planned between 42 and 42 -week postmenstrual age. Cross-sectional and longitudinal linear regression analyses were performed.
Seventy-nine mother-child pairs were included. Median (interquartile range) TVol increased from 7.6 (7.1; 8.5) cm at 22 weeks to 36.5 (33.8; 40.9) cm at 32 weeks. Median neonatal %BF was 14.3% (11.7; 17.0). TVol at 22 weeks (β = -1.58, 95% CI -2.45; -0.70, explained variance 31%) was negatively associated with %BF, but no associations were found at 26 and 32 weeks of gestation. TVol growth between 22 and 32 weeks of gestation (explained variance 18%) was also statistically significantly negatively associated with %BF.
Foetal TVol is a promising 3D US marker for prediction of neonatal adiposity from mid-gestation onward.
肥胖倾向被认为起源于产前时期。需要产前标志物来识别有新生儿肥胖风险的胎儿，作为儿童肥胖的早期标志物。
本研究的目的是评估从妊娠中期开始胎儿大腿部体积分数（TVol）与新生儿脂肪质量百分比之间的关联。
在这项围产期队列研究中，纳入了单胎足月出生的婴儿。在妊娠22、26和32周时通过三维超声扫描（3D US）测量胎儿TVol。计划在月经龄42至42周之间进行新生儿身体成分测量（体脂百分比（%BF））。进行了横断面和纵向线性回归分析。
纳入了79对母婴。TVol中位数（四分位间距）从22周时的7.6（7.1；8.5）cm增加到32周时的36.5（33.8；40.9）cm。新生儿%BF中位数为14.3%（11.7；17.0）。22周时的TVol（β = -1.58，95%CI -2.45；-0.70，解释方差31%）与%BF呈负相关，但在妊娠26和32周时未发现相关性。妊娠22至32周期间的TVol增长（解释方差18%）也与%BF在统计学上显著负相关。
胎儿TVol是一种有前景的三维超声标志物，可用于从妊娠中期开始预测新生儿肥胖。
