Division of Fetal Imaging, Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, MI 48073-6769, USA.
Ultrasound Obstet Gynecol. 2009 Apr;33(4):441-6. doi: 10.1002/uog.6317.
The main goal was to investigate the relationship between prenatal sonographic parameters and birth weight in predicting neonatal body composition.
Standard fetal biometry and soft tissue parameters were assessed prospectively in third-trimester pregnancies using three-dimensional ultrasonography. Growth parameters included biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), mid-thigh circumference and femoral diaphysis length (FDL). Soft tissue parameters included fractional arm volume (AVol) and fractional thigh volume (TVol) that were derived from 50% of the humeral or femoral diaphysis lengths, respectively. Percentage of neonatal body fat (%BF) was determined within 48 h of delivery using a pediatric air displacement plethysmography system based on principles of whole-body densitometry. Correlation and stepwise multiple linear regression analyses were performed with potential prenatal predictors and %BF as the outcome variable.
Eighty-seven neonates were studied with a mean +/- SD %BF of 10.6 +/- 4.6%. TVol had the greatest correlation with newborn %BF of all single-parameter models. This parameter alone explained 46.1% of the variability in %BF and the best stepwise multiple linear regression model was: %BF = 0.129 (TVol) - 1.03933 (P < 0.001). Birth weight similarly explained 44.7% of the variation in %BF. AC and estimated fetal weight (EFW) accounted for only 24.8% and 30.4% of the variance in %BF, respectively. Skeletal growth parameters, such as FDL (14.2%), HC (7.9%) and BPD (4.0%), contributed the least towards explaining the variance in %BF.
During the late third trimester of pregnancy %BF is most highly correlated with TVol. Similar to actual birth weight, this soft tissue parameter accounts for a significant improvement in explaining the variation in neonatal %BF compared with fetal AC or EFW alone.
主要目的是研究产前超声参数与出生体重在预测新生儿体成分中的关系。
使用三维超声对妊娠晚期胎儿进行标准胎儿生物测量和软组织参数的前瞻性评估。生长参数包括双顶径（BPD）、头围（HC）、腹围（AC）、大腿中部周长和股骨骨干长度（FDL）。软组织参数包括分别源自肱骨或股骨骨干长度 50%的分臂容积（AVol）和分大腿容积（TVol）。使用基于全身密度测定原理的儿科空气置换体描仪系统，在分娩后 48 小时内确定新生儿体脂肪百分比（%BF）。进行相关和逐步多元线性回归分析，以潜在的产前预测因子和%BF作为因变量。
对 87 例新生儿进行了研究，平均（±SD）%BF 为 10.6（±4.6）%。在所有单参数模型中，TVol 与新生儿%BF 的相关性最大。该参数单独解释了%BF 可变性的 46.1%，最佳逐步多元线性回归模型为：%BF=0.129（TVol）-1.03933（P<0.001）。出生体重同样解释了 44.7%的%BF 变化。AC 和估计胎儿体重（EFW）仅分别解释了%BF 变异的 24.8%和 30.4%。骨骼生长参数，如 FDL（14.2%）、HC（7.9%）和 BPD（4.0%），对解释%BF 变异的贡献最小。
在妊娠晚期，%BF 与 TVol 的相关性最高。与实际出生体重相似，与单独的胎儿 AC 或 EFW 相比，该软组织参数显著提高了对新生儿%BF 变化的解释能力。
