Anglim Breffini, Farah Nadine, O'Connor Clare, Daly Niamh, Kennelly Mairead M, Turner Michael J
a UCD Centre for Human Reproduction , Coombe Women and Infants Hospital , Dublin , Ireland.
J Obstet Gynaecol. 2017 Jul;37(5):591-594. doi: 10.1080/01443615.2017.1283303. Epub 2017 Apr 1.
Maternal obesity is an emerging challenge in contemporary obstetrics. To date there has been no study analysing the relationship between specific maternal body composition measurements and foetal soft-tissue measurements. The aim of this study was to determine whether measurement of maternal body composition at booking predicts foetal soft-tissue trajectories in the third trimester. We analysed the relationship between foetal thigh in the third trimester and both maternal BMI and body composition using the Tanita digital scales in the first trimester. Foetal subcutaneous thigh tissue measurements were obtained at intervals of 28, 32 and 36 weeks of gestation. A total of 160 women were identified. There was a direct correlation between MTST at 36 weeks and BMI (p = .002). There was a positive correlation between MTST at 36 weeks and leg fat mass (p = .13) and leg fat free mass (p = .013). There was a positive correlation between arm fat free mass and MTST at 36 weeks. We showed there is an association between maternal fat distribution and foetal subcutaneous thigh tissue measurements. MTST may be more useful in determining if a child is at risk of macrosomia. Impact statement Previous studies have suggested that maternal obesity programmes intrauterine foetal adiposity and growth. The aim of this study was to examine the relationship in a high-risk obstetric population between measurements of maternal body composition in early pregnancy and the assessment of foetal adiposity in the third trimester using serial ultrasound measurements of mid-thigh soft-tissue thickness. BMI is only a surrogate measurement of fat and does not measure fat distribution. Our study shows the distribution of both maternal fat and fat-free mass in early pregnancy may be positively associated with foetal soft-tissue measurements in the third trimester. Maternal arthropometric measurements other than BMI may help predict babies at risk of macrosomia and neonatal adiposity.
孕妇肥胖是当代产科领域一个新出现的挑战。迄今为止，尚无研究分析特定孕妇身体成分测量值与胎儿软组织测量值之间的关系。本研究的目的是确定在初次产检时测量孕妇身体成分是否能预测孕晚期胎儿软组织的生长轨迹。我们使用Tanita数字秤在孕早期分析了孕晚期胎儿大腿与孕妇BMI及身体成分之间的关系。在妊娠28、32和36周时定期测量胎儿大腿皮下组织厚度。共纳入160名女性。36周时的大腿中段皮下组织厚度（MTST）与BMI呈直接相关（p = 0.002）。36周时的MTST与腿部脂肪量（p = 0.13）和腿部去脂体重（p = 0.013）呈正相关。36周时手臂去脂体重与MTST呈正相关。我们发现孕妇脂肪分布与胎儿大腿皮下组织测量值之间存在关联。MTST在确定胎儿是否有巨大儿风险方面可能更有用。影响声明 以往研究表明，孕妇肥胖会影响胎儿宫内脂肪沉积和生长。本研究的目的是在高危产科人群中，通过对大腿中段软组织厚度进行系列超声测量，研究孕早期孕妇身体成分测量值与孕晚期胎儿脂肪沉积评估之间的关系。BMI只是脂肪的一种替代测量指标，无法测量脂肪分布。我们的研究表明，孕早期孕妇脂肪和去脂体重的分布可能与孕晚期胎儿软组织测量值呈正相关。除BMI外，孕妇人体测量指标可能有助于预测有巨大儿和新生儿肥胖风险的婴儿。
