Guorong Yao, Yunfeng F U, Yanli L I, Caiyun Zhou, Weiguo L V
Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China; Department of Obstetrics and Gynecology, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Mar 25;46(2):173-178. doi: 10.3785/j.issn.1008-9292.2017.04.09.
To study the expression of DNAJB11 protein in epithelial ovarian cancer tissues and its clinical significance. Immunohistochemistry was used to examine DNAJB11 expressions in 105 tissue specimens of ovarian epithelial carcinoma, 23 normal ovarian tissues, 17 tissues of benign tumor, and 13 tissues of of borderline tumor. The correlations between protein expression and clinicopathological factors were analyzed by Chi square test.The correlations between protein expression and survival were analyzed by Kaplan-Meier and Cox regression. Positive expression of DNAJB11 protein was observed in 0.0% in normal ovary and benign tumor, 7.69% in borderline tumor, and 78.10% in epithelial ovarian cancer, respectively. Positive expression of DNAJB11 protein was significantly higher than the rest of the ovarian tissues and normal ovarian tissues (<0.001).Higher expression of DNAJB11 was more prevalent in tissues from patients with advanced FIGO stages, high serum CA125, poor histological differentiation, and serous cancer. Kaplan-Meier curves revealed that higher expression of DNAJB11 was significantly associated with poor disease-free survival and overall survival.Multivariate survival analysis revealed that strong positive expression of DNAJB11 was an independent prognostic factor for disease-free survival and overall survival. DNAJB11 may play a role in tumorigenesis and progression of epithelial ovarian cancer.Strong positive expression of DNAJB11 was an independent prognostic factor in epithelial ovarian cancer.
研究DNAJB11蛋白在上皮性卵巢癌组织中的表达及其临床意义。采用免疫组织化学法检测105例卵巢上皮癌组织标本、23例正常卵巢组织、17例良性肿瘤组织及13例交界性肿瘤组织中DNAJB11的表达。采用卡方检验分析蛋白表达与临床病理因素之间的相关性。采用Kaplan-Meier法和Cox回归分析蛋白表达与生存之间的相关性。DNAJB11蛋白在正常卵巢和良性肿瘤中的阳性表达率分别为0.0%，在交界性肿瘤中为7.69%，在上皮性卵巢癌中为78.10%。DNAJB11蛋白的阳性表达显著高于其他卵巢组织和正常卵巢组织（<0.001）。DNAJB11的高表达在国际妇产科联盟（FIGO）晚期、血清CA125水平高、组织学分化差及浆液性癌患者的组织中更为普遍。Kaplan-Meier曲线显示，DNAJB11的高表达与无病生存期和总生存期差显著相关。多因素生存分析显示，DNAJB11的强阳性表达是无病生存期和总生存期的独立预后因素。DNAJB11可能在上皮性卵巢癌的发生和发展中起作用。DNAJB11的强阳性表达是上皮性卵巢癌的独立预后因素。
