Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Biol Psychol. 2019 Jul;145:8-16. doi: 10.1016/j.biopsycho.2019.03.003. Epub 2019 Mar 30.
Prepulse inhibition (PPI) is a sensorimotor gating mechanism that reduces interfering influences to the neural processing of incoming stimuli, and is associated with several neurodevelopmental disorders. To date, research on PPI and neurodevelopmental disorders has primarily been in cross-sectional, clinical settings. In this prospective, epidemiologic study, we used a data-driven prediction model to identify socio-demographic predictors of PPI in children and adolescents from Mexico City to inform future etiologic studies evaluating PPI. We conducted variable selection and validation using a modified version of the multiple imputation random lasso (MIRL) variable selection algorithm. MIRL identified six predictors of PPI at a stimulus onset asynchrony of 120 ms or 240 ms. Of those six predictors, maternal education, birthweight, and total breastfeeding months were highlighted as previously unstudied variables associated with enhanced PPI. Our findings highlight the potential value of PPI as an adjunct screening tool for identifying children at risk for neurodevelopmental disorders and underscore the relevance for validation research on this topic.
前脉冲抑制（PPI）是一种感觉运动门控机制，可减少传入刺激的神经处理过程中的干扰影响，与多种神经发育障碍有关。迄今为止，关于 PPI 和神经发育障碍的研究主要是在横断面、临床环境中进行的。在这项前瞻性、流行病学研究中，我们使用数据驱动的预测模型来识别墨西哥城儿童和青少年 PPI 的社会人口统计学预测因素，为评估 PPI 的未来病因研究提供信息。我们使用改进的多重插补随机lasso（MIRL）变量选择算法进行变量选择和验证。MIRL 在刺激起始时的 120ms 或 240ms 时确定了 PPI 的六个预测因子。在这六个预测因子中，母亲的教育程度、出生体重和总母乳喂养月数被突出为与增强 PPI 相关的以前未研究过的变量。我们的研究结果强调了 PPI 作为识别有神经发育障碍风险儿童的辅助筛查工具的潜在价值，并强调了对此主题进行验证研究的相关性。
