Maimónides Institute for Research in Biomedicine of Cordoba (IMIBIC), 14004 Córdoba, Spain; Rheumatology Department, Reina Sofia University Hospital, Avda. Menendez Pidal, s/n., 14004 Córdoba, Spain; Córdoba University (UCO), 14004 Córdoba, Spain.
Maimónides Institute for Research in Biomedicine of Cordoba (IMIBIC), 14004 Córdoba, Spain; Rheumatology Department, Reina Sofia University Hospital, Avda. Menendez Pidal, s/n., 14004 Córdoba, Spain; Córdoba University (UCO), 14004 Córdoba, Spain.
Joint Bone Spine. 2018 Jul;85(4):447-453. doi: 10.1016/j.jbspin.2017.07.006. Epub 2017 Jul 25.
The objectives of this study were: (1) to compare the prevalence of cardiovascular disease and cardiovascular risk factors among different phenotypes of spondyloarthritis (SpA); (2) to assess the differences in cardiovascular disease and cardiovascular risk factors between two geographical areas, i.e. Northern Europe vs. Mediterranean region; (3) to identify potential predictive factors for high Framingham Risk Score regarding disease features in SpA and geographical area.
Ancillary analysis of the international, multicentric, observational, cross-sectional ASAS-COMOSPA study. Cardiovascular disease and cardiovascular risk factors were compared depending on SpA phenotype and geographical regions. Potential factors associated with higher cardiovascular risk (i.e. Framingham Risk Score) were determined by a multiple logistic regression.
The most frequent cardiovascular risk factor and cardiovascular disease were smoking (31.2%) and ischemic heart disease (3.2%), respectively. Regarding SpA phenotype, axial SpA patients showed significantly lower prevalence (P<0.05) of hypertension (19.2% vs. 33.8% vs. 26.6% for axial, peripheral and mixed phenotypes, respectively), type 2 diabetes mellitus (4.3% vs. 8.5% vs. 7.4%), dyslipidemia (13.9% vs. 28.4% vs. 15.2%) and ischemic heart disease (2.4% vs. 7.0% vs. 3.2%). Regarding geographical area, a higher frequency of hypertension (34.7% vs. 19.4%,), dyslipidemia (19.3% vs. 14.4%), obesity (29.3% vs. 20.7%) and ischemic heart disease (6.2% vs. 1.8%) was observed for Northern Europe vs. Mediterranean Region, respectively.
Our results suggest that SpA phenotype and geographical area are associated with the prevalence of cardiovascular risk factors and the cardiovascular risk itself, observed in patients in the ASAS-COMOSPA cohort.
本研究的目的是：(1)比较不同脊柱关节炎（SpA）表型患者的心血管疾病和心血管危险因素的患病率；(2)评估两个地理区域（北欧与地中海地区）间心血管疾病和心血管危险因素的差异；(3)确定 SpA 疾病特征和地理区域中Framingham 风险评分高的潜在预测因素。
对国际、多中心、观察性、横断面 ASAS-COMOSPA 研究进行辅助分析。根据 SpA 表型和地理区域比较心血管疾病和心血管危险因素。通过多因素逻辑回归确定与更高心血管风险（即Framingham 风险评分）相关的潜在因素。
最常见的心血管危险因素和心血管疾病分别为吸烟（31.2%）和缺血性心脏病（3.2%）。就 SpA 表型而言，中轴型 SpA 患者的高血压（19.2% vs. 33.8% vs. 26.6%，中轴型、外周型和混合表型分别）、2 型糖尿病（4.3% vs. 8.5% vs. 7.4%）、血脂异常（13.9% vs. 28.4% vs. 15.2%）和缺血性心脏病（2.4% vs. 7.0% vs. 3.2%）的患病率显著更低（P<0.05）。就地理区域而言，与地中海地区相比，北欧地区高血压（34.7% vs. 19.4%）、血脂异常（19.3% vs. 14.4%）、肥胖（29.3% vs. 20.7%）和缺血性心脏病（6.2% vs. 1.8%）的发生率更高。
我们的研究结果表明，ASAS-COMOSPA 队列患者中，SpA 表型和地理区域与心血管危险因素的患病率和心血管风险本身相关。
