Wagan Abrar Ahmed, Surahyo Paras
Abrar Ahmed Wagan, MBBS, FCPS, FACR Associate Professor of Rheumatology, Indus Medical College, Tando Mohammad Khan, Pakistan.
Paras Surahyo, MBBS, FCPS Assistant Professor of Radiology Bilawal Medical College, Jamshoro, Pakistan.
Pak J Med Sci. 2024 Jan-Feb;40(3Part-II):438-443. doi: 10.12669/pjms.40.3.7265.
To determine the frequency of modifiable cardiovascular risk factors in the Pakistani cohort with Ankylosing Spondylitis (AS).
After IRB approval, a cross-sectional study was conducted among patients of AS, at the Department of Rheumatology Indus Medical College, Tando Mohammad Khan, from 15 March to 15 September, 2022. After obtaining demographic data, other parameters such as blood pressure (BP) and body mass index were recorded. In addition, a 5 ml blood sample was collected to assess their serum lipid profile, and fasting blood sugar levels. Using the laboratory data, the Framingham cardiovascular risk score was calculated for each patient and they were categorized into low, intermediate, or high-risk categories.
Total 131 cases of ankylosing spondylitis: frequency of modifiable risk factors were: obesity (75.6%), high TG level (62.6%), high risk FRS score (40.5%), high LDL level (38.1%), low HDL (34.4%), hypertension (30.5%), diabetes mellitus (26.7%), high cholesterol level (17.6%), smoking (16%). In univariate analysis AS cases shows that increasing disease duration was associated with more risk of modifiable risk factors (p<0.05), on multivariate analysis, a positive association of age, diastolic blood pressure, smoking, diabetes mellitus, DMARDS, herbal medication-but not statistically significant (p>0.05).
In chronic AS there's higher prevalence of modifiable cardiovascular risk factors, earlier recognition and effective management helps in prevention of future cardiovascular events.
确定巴基斯坦强直性脊柱炎（AS）队列中可改变的心血管危险因素的频率。
经机构审查委员会（IRB）批准，于2022年3月15日至9月15日在坦多穆罕默德汗市印度医学院风湿病科对AS患者进行了一项横断面研究。获取人口统计学数据后，记录血压（BP）和体重指数等其他参数。此外，采集5毫升血样以评估其血脂谱和空腹血糖水平。利用实验室数据，为每位患者计算弗雷明汉心血管风险评分，并将他们分为低、中或高风险类别。
共131例强直性脊柱炎患者：可改变危险因素的频率为：肥胖（75.6%）、高甘油三酯水平（62.6%）、高风险弗雷明汉风险评分（40.5%）、高低密度脂蛋白水平（38.1%）、低高密度脂蛋白（34.4%）、高血压（30.5%）、糖尿病（26.7%）、高胆固醇水平（17.6%）、吸烟（16%）。单因素分析显示，AS病例中疾病持续时间增加与可改变危险因素的风险增加相关（p<0.05），多因素分析显示，年龄、舒张压、吸烟、糖尿病、改善病情抗风湿药、草药治疗呈正相关，但无统计学意义（p>0.05）。
在慢性AS中，可改变的心血管危险因素患病率较高，早期识别和有效管理有助于预防未来心血管事件。
