来自白木香花芽的二苯甲酮苷类化合物。
Benzophenone glycosides from the flower buds of Aquilaria sinensis.
作者信息
Yuan Hanwen, Zhao Jianping, Wang Mei, Khan Shabana I, Zhai Chunmei, Xu Qiongming, Huang Jianhua, Peng Caiyun, Xiong Guanghua, Wang Wei, Khan Ikhlas A
机构信息
TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677, USA.
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677, USA.
出版信息
Fitoterapia. 2017 Sep;121:170-174. doi: 10.1016/j.fitote.2017.07.013. Epub 2017 Jul 25.
Four new benzophenone glycosides named as aquilaside A-D (1-4) along with five known compounds (5-9) were isolated from the methanol extract of the flower buds of Aquilaria sinensis. Their structures were elucidated on the basis of 1D and 2D NMR and mass spectroscopic analyses. All purified compounds were evaluated for their anti-inflammatory and cytotoxic activities. Aquilasides B and C displayed moderate cytotoxicity against SK-MEL cells with IC of 17.0 and 12.0μM and weak NF-κB inhibitive activity at 100μM with 30% and 60%, respectively.
从白木香花芽的甲醇提取物中分离得到4个新的二苯甲酮苷，命名为沉香苷A-D（1-4）以及5个已知化合物（5-9）。通过一维和二维核磁共振及质谱分析确定了它们的结构。对所有纯化的化合物进行了抗炎和细胞毒性活性评价。沉香苷B和C对SK-MEL细胞显示出中等细胞毒性，IC50分别为17.0和12.0μM，在100μM时对NF-κB具有较弱的抑制活性，分别为30%和60%。
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