一种从白木香新鲜茎中提取的新型降解倍半萜。

A novel degraded sesquiterpene from the fresh stem of Aquilaria sinensis.

作者信息

Peng Ke, Mei Wen-Li, Zhao You-Xing, Tan Le-He, Wang Qing-Huang, Dai Hao-Fu

机构信息

National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China.

出版信息

J Asian Nat Prod Res. 2011 Oct;13(10):951-5. doi: 10.1080/10286020.2011.598860.

DOI:10.1080/10286020.2011.598860

PMID:21972811

Abstract

A novel degraded sesquiterpene, named aquilarin B (1), together with two known compounds (2 and 3), was isolated from the EtOH extract of the fresh stem of Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY, HMBC, and ROESY). The cytotoxic activities of the three compounds against three human tumor cell lines K562, SMMC-7721, and SGC-7901 were evaluated, and compound 3 exhibited obvious cytotoxic activity.

摘要

从白木香新鲜茎的乙醇提取物中分离出一种名为沉香菌素B（1）的新型降解倍半萜以及两种已知化合物（2和3）。通过包括一维和二维核磁共振（HMQC、氢-氢化学位移相关谱、异核多键相关谱和旋转坐标系下的核欧沃豪斯效应谱）在内的光谱方法阐明了它们的结构。评估了这三种化合物对三种人类肿瘤细胞系K562、SMMC-7721和SGC-7901的细胞毒性活性，化合物3表现出明显的细胞毒性活性。