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拟伪海蝶鱼素：来自海鞭拟伪海蝶鱼的具有抗炎和镇痛作用的天然产物。

The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae.

作者信息

Look S A, Fenical W, Jacobs R S, Clardy J

出版信息

Proc Natl Acad Sci U S A. 1986 Sep;83(17):6238-40. doi: 10.1073/pnas.83.17.6238.

DOI:10.1073/pnas.83.17.6238
PMID:2875457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC386477/
Abstract

The Caribbean sea whip Pseudopterogorgia elisabethae (Octocorallia, Cnidaria) has been found to contain the pseudopterosins, a newly described class of natural products, which have been characterized as diterpene-pentoseglycosides. The pseudopterosins possess anti-inflammatory and analgesic properties that exceed, in our assays, the potencies of existing drugs such as indomethacin. As anti-inflammatory agents, the pseudopterosins appear to modify the arachidonic acid cascade by an as yet undefined mechanism of pharmacological action.

摘要

加勒比海鞭珊瑚（Pseudopterogorgia elisabethae，八放珊瑚亚纲，刺胞动物门）被发现含有假蕨素，这是一类新描述的天然产物，其特征为二萜-戊糖糖苷。在我们的试验中，假蕨素具有的抗炎和镇痛特性超过了现有药物如消炎痛的效力。作为抗炎剂，假蕨素似乎通过一种尚未明确的药理作用机制来改变花生四烯酸级联反应。

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The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae.拟伪海蝶鱼素：来自海鞭拟伪海蝶鱼的具有抗炎和镇痛作用的天然产物。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6238-40. doi: 10.1073/pnas.83.17.6238.
2
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12-hydroxy-E-gamma-bisabolene, a new sesquiterpene alcohol from a Caribbean sea whip of the genus Pseudopterogorgia (Gorgonacea, Cnidaria).12-羟基-E-γ-红没药烯，一种从拟软柳珊瑚属（柳珊瑚目，刺胞动物门）的加勒比海鞭珊瑚中分离得到的新型倍半萜醇。
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J Org Chem. 2000 Mar 10;65(5):1390-8. doi: 10.1021/jo9914869.

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Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics.弱镇痛药和非镇痛药对苯醌诱发小鼠扭体反应频率的拮抗作用。
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12-hydroxy-E-gamma-bisabolene, a new sesquiterpene alcohol from a Caribbean sea whip of the genus Pseudopterogorgia (Gorgonacea, Cnidaria).12-羟基-E-γ-红没药烯，一种从拟软柳珊瑚属（柳珊瑚目，刺胞动物门）的加勒比海鞭珊瑚中分离得到的新型倍半萜醇。
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