Maruyama S, Murawaki Y, Hirayama C
Res Commun Chem Pathol Pharmacol. 1986 Jul;53(1):3-21.
In ethanol-fed rats for 4 or 7 weeks, hepatic HMG-CoA reductase activity was significantly increased, and correlated positively with hepatic microsomal gamma-GTP activity. By contrast, hepatic cholesterol 7 alpha-hydroxylase activity was decreased in these rats. The content of hepatic cholesterol and levels of serum cholesterol and HDL-cholesterol were significantly increased in these rats, correlating significantly with hepatic HMG-CoA reductase activity, but not with hepatic cholesterol 7 alpha-hydroxylase activity. These results suggest that the increase in serum levels of cholesterol and HDL-cholesterol by ethanol feeding is mainly regulated by the enhanced cholesterol synthesis in the liver.
在给予乙醇4周或7周的大鼠中，肝脏HMG-CoA还原酶活性显著增加，且与肝脏微粒体γ-GTP活性呈正相关。相比之下，这些大鼠的肝脏胆固醇7α-羟化酶活性降低。这些大鼠的肝脏胆固醇含量、血清胆固醇和高密度脂蛋白胆固醇水平显著升高，与肝脏HMG-CoA还原酶活性显著相关，但与肝脏胆固醇7α-羟化酶活性无关。这些结果表明，乙醇喂养导致的血清胆固醇和高密度脂蛋白胆固醇水平升高主要受肝脏中胆固醇合成增强的调节。
