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Am J Public Health. 1998 Aug;88(8):1208-12. doi: 10.2105/ajph.88.8.1208.
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Ascorbic acid and cholesterol gallstones.抗坏血酸与胆固醇胆结石
Med Hypotheses. 1993 Feb;40(2):81-4. doi: 10.1016/0306-9877(93)90132-a.
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Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators.
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Gallstone disease among Japanese men in relation to obesity, glucose intolerance, exercise, alcohol use, and smoking.日本男性胆结石病与肥胖、葡萄糖不耐受、运动、饮酒及吸烟的关系。
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Gallstone formation in guinea pigs under different dietary conditions. Effect of vitamin C on bile acid pattern.不同饮食条件下豚鼠胆结石的形成。维生素C对胆汁酸模式的影响。
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Role of gallbladder mucus hypersecretion in the evolution of cholesterol gallstones.胆囊黏液分泌过多在胆固醇结石形成过程中的作用。
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Vitamin C in the control of hypercholesterolemia in man.
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Arachidonic acid stimulates mucin secretion in prairie dog gallbladder.
Am J Physiol. 1983 Jul;245(1):G92-8. doi: 10.1152/ajpgi.1983.245.1.G92.
8
Pigment vs cholesterol cholelithiasis: comparison of stone and bile composition.色素性胆结石与胆固醇性胆结石：结石及胆汁成分比较
Am J Dig Dis. 1974 Jul;19(7):585-90. doi: 10.1007/BF01073011.
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Cholesterol: vitamin C controls its transformation to bile acids.胆固醇：维生素C控制其向胆汁酸的转化。
Science. 1973 Feb 16;179(4074):702-4. doi: 10.1126/science.179.4074.702.
10
Effects of chronic ethanol administration on hepatic cholesterol and bile acid synthesis in relation to serum high density lipoprotein cholesterol in rats.长期给予乙醇对大鼠肝脏胆固醇和胆汁酸合成的影响及其与血清高密度脂蛋白胆固醇的关系
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美国成年人血清中的抗坏血酸及胆囊疾病的其他相关因素。

Serum ascorbic acid and other correlates of gallbladder disease among US adults.

作者信息

Simon J A, Hudes E S

机构信息

General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, Calif. 94121, USA.

出版信息

Am J Public Health. 1998 Aug;88(8):1208-12. doi: 10.2105/ajph.88.8.1208.

DOI:10.2105/ajph.88.8.1208
PMID:9702150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1508320/
Abstract

OBJECTIVES

This study examined the correlates of clinical gallbladder disease among US adults and whether serum ascorbic acid levels are associated with a decreased prevalence of gallbladder disease.

METHODS

Cross-sectional analyses of data from the Second National Health and Nutrition Examination Survey were conducted.

RESULTS

A total of 384 women (8%) and 107 men (3%) reported a history of gallstone disease, and 347 women (7%) and 81 men (2%) reported a history of cholecystectomy. An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men.

CONCLUSIONS

Ascorbic acid, which affects the catabolism of cholesterol to bile acids and, in turn, the development of gallbladder disease in experimental animals, may reduce the risk of clinical gallbladder disease in humans.

摘要

目的

本研究调查了美国成年人临床胆囊疾病的相关因素，以及血清抗坏血酸水平是否与胆囊疾病患病率降低相关。

方法

对第二次全国健康和营养检查调查的数据进行横断面分析。

结果

共有384名女性（8%）和107名男性（3%）报告有胆结石病史，347名女性（7%）和81名男性（2%）报告有胆囊切除术病史。在女性中，血清抗坏血酸水平与临床胆囊疾病之间呈倒U形关系，而在男性中未发现这种关系。

结论

抗坏血酸会影响胆固醇向胆汁酸的分解代谢，进而影响实验动物胆囊疾病的发展，它可能会降低人类临床胆囊疾病的风险。