美国成年人血清中的抗坏血酸及胆囊疾病的其他相关因素。
Serum ascorbic acid and other correlates of gallbladder disease among US adults.
作者信息
Simon J A, Hudes E S
机构信息
General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, Calif. 94121, USA.
出版信息
Am J Public Health. 1998 Aug;88(8):1208-12. doi: 10.2105/ajph.88.8.1208.
OBJECTIVES
This study examined the correlates of clinical gallbladder disease among US adults and whether serum ascorbic acid levels are associated with a decreased prevalence of gallbladder disease.
METHODS
Cross-sectional analyses of data from the Second National Health and Nutrition Examination Survey were conducted.
RESULTS
A total of 384 women (8%) and 107 men (3%) reported a history of gallstone disease, and 347 women (7%) and 81 men (2%) reported a history of cholecystectomy. An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men.
CONCLUSIONS
Ascorbic acid, which affects the catabolism of cholesterol to bile acids and, in turn, the development of gallbladder disease in experimental animals, may reduce the risk of clinical gallbladder disease in humans.
目的
本研究调查了美国成年人临床胆囊疾病的相关因素，以及血清抗坏血酸水平是否与胆囊疾病患病率降低相关。
方法
对第二次全国健康和营养检查调查的数据进行横断面分析。
结果
共有384名女性（8%）和107名男性（3%）报告有胆结石病史，347名女性（7%）和81名男性（2%）报告有胆囊切除术病史。在女性中，血清抗坏血酸水平与临床胆囊疾病之间呈倒U形关系，而在男性中未发现这种关系。
结论
抗坏血酸会影响胆固醇向胆汁酸的分解代谢，进而影响实验动物胆囊疾病的发展，它可能会降低人类临床胆囊疾病的风险。
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