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CAR T cells targeting solid tumors: carcinoembryonic antigen (CEA) proves to be a safe target.

作者信息

Holzinger Astrid, Abken Hinrich

机构信息

Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.

Clinic I Internal Medicine, University Hospital Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.

出版信息

Cancer Immunol Immunother. 2017 Nov;66(11):1505-1507. doi: 10.1007/s00262-017-2045-4. Epub 2017 Jul 28.

DOI:10.1007/s00262-017-2045-4
PMID:28755091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11029415/
Abstract
摘要

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本文引用的文献

1
The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity.第一代癌胚抗原（CEACAM5）特异性嵌合抗原受体T细胞的临床疗效受到持久性差和短暂的预处理依赖性呼吸毒性的限制。
Cancer Immunol Immunother. 2017 Nov;66(11):1425-1436. doi: 10.1007/s00262-017-2034-7. Epub 2017 Jun 28.
2
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA Metastatic Colorectal Cancers.靶向癌胚抗原的嵌合抗原受体T细胞疗法用于转移性结直肠癌的I期剂量递增试验。
Mol Ther. 2017 May 3;25(5):1248-1258. doi: 10.1016/j.ymthe.2017.03.010. Epub 2017 Mar 31.
3
Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases.用于CEA阳性肝转移的肝内动脉嵌合抗原受体修饰T细胞疗法的I期肝转移免疫治疗研究
Clin Cancer Res. 2015 Jul 15;21(14):3149-59. doi: 10.1158/1078-0432.CCR-14-1421. Epub 2015 Apr 7.
4
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.针对癌胚抗原的 T 细胞可以介导转移性结直肠癌的消退，但会引起严重的短暂性结肠炎。
Mol Ther. 2011 Mar;19(3):620-6. doi: 10.1038/mt.2010.272. Epub 2010 Dec 14.