Chong-Nguyen Caroline, Duboc Henri, Sokol Harry
AP-HP, hôpital Cochin, service de cardiologie, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
AP-HP, hôpital Louis-Mourier, service de gastro-entérologie, 92700 Colombes, France.
Presse Med. 2017 Jul-Aug;46(7-8 Pt 1):708-713. doi: 10.1016/j.lpm.2017.06.005. Epub 2017 Jul 26.
The gut microbiota is considered as our other "brain" and is implicated in several regulation of physiological metabolisms. The circulating level of TMAO, a metabolite of the gut microbiota, is directly correlated to the occurrence of cardiovascular events. Bile acids are protective metabolites against cardiovascular diseases through their anti-inflammatory and anti-atherogenic effects. The disturbance in the metabolism and the composition of the gut microbiota is called "dysbiosis". Understanding the implication of the gut microbiota and developing new therapeutic strategies are promising research fields to manage metabolic and cardiovascular diseases.
肠道微生物群被视为我们的另一个“大脑”，并参与多种生理代谢的调节。肠道微生物群的代谢产物氧化三甲胺（TMAO）的循环水平与心血管事件的发生直接相关。胆汁酸通过其抗炎和抗动脉粥样硬化作用，是预防心血管疾病的保护性代谢产物。肠道微生物群的代谢和组成紊乱被称为“生态失调”。了解肠道微生物群的作用并开发新的治疗策略是管理代谢性疾病和心血管疾病的有前景的研究领域。
