Garg Bhawan Deep, Sharma Deepak, Bansal Anju
a Department of Neonatology , Surya Children's Medicare Pvt. Ltd , Mumbai , India.
b Department of Neonatology , National Institute of Medical Sciences , Jaipur , India.
J Matern Fetal Neonatal Med. 2018 Nov;31(22):3051-3064. doi: 10.1080/14767058.2017.1361925. Epub 2017 Aug 9.
Necrotizing enterocolitis (NEC) is among the most serious gastrointestinal emergency in very low birth weight (VLBW), extremely low birth weight (ELBW) and extremely low gestational age neonates (ELGAN), affecting 7-14% of these neonates. Despite extensive research, the underlying aetiology of NEC still remains blurred. Due to high mortality, morbidity and its delayed presentation, early detection of NEC is considered to be lifesaving. A number of biomarkers have been studied for early detection and prediction of severity of NEC but till date, no ideal marker has been discovered. Molecular techniques like proteomic and metabolomic have recently emerged in the field for the development of biomarkers for early detection and understanding the pathophysiology of NEC. We did literature search for identifying all biomarkers that have been used for the detection of NEC and, in this review article, we discuss these biomarkers along with the available current evidence.
坏死性小肠结肠炎（NEC）是极低出生体重（VLBW）、超低出生体重（ELBW）和极早早产龄新生儿（ELGAN）中最严重的胃肠道急症之一，影响这些新生儿中的7%至14%。尽管进行了广泛研究，但NEC的潜在病因仍不明确。由于其高死亡率、高发病率以及症状出现较晚，NEC的早期检测被认为是挽救生命的关键。已经对多种生物标志物进行了研究，用于NEC的早期检测和严重程度预测，但迄今为止，尚未发现理想的标志物。蛋白质组学和代谢组学等分子技术最近在该领域崭露头角，用于开发早期检测NEC的生物标志物并理解其病理生理学。我们进行了文献检索，以识别所有用于检测NEC的生物标志物，在这篇综述文章中，我们将结合现有证据对这些生物标志物进行讨论。
