1 Department of Surgery, Medical, and Social Sciences, University of Alcalá , Alcalá de Henares, Madrid, Spain .
2 Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), University of Alcalá , Alcalá de Henares, Madrid, Spain .
Tissue Eng Part C Methods. 2017 Dec;23(12):863-880. doi: 10.1089/ten.TEC.2017.0167. Epub 2017 Oct 27.
In this report, we review the use of the New Zealand White rabbit as the experimental animal for several models of abdominal wall repair. For the repair of an abdominal wall defect, such as a hernia in clinical practice, multiple types of prosthetic material exist. Before their marketing, each of these biomaterials needs to be tested in a preclinical setting to confirm its biocompatibility and appropriate behavior at the different tissue interfaces. For preclinical trials, we have always used the New Zealand White rabbit as the model owing to its ease of handling and suitable size. This size allows for laparoscopic studies designed to follow the behavior in real time of a biomaterial implanted at the peritoneal interface, a delicate interface that often gives rise to complications in human practice. The size of the rabbit also offers a sufficiently large number of implant samples to be harvested for a complete battery of tests at several time points postimplant. In this review, we first describe the models established and then provide the results obtained so far using these models to test the different types of biomaterial. We end our review with a discussion of the clinical implications of these results.
在本报告中，我们回顾了新西兰白兔在几种腹壁修复模型中的应用。对于腹壁缺损的修复，如临床上的疝，存在多种类型的假体材料。在这些生物材料上市之前，每种生物材料都需要在临床前环境中进行测试，以确认其生物相容性和在不同组织界面的适当行为。对于临床前试验，我们一直使用新西兰白兔作为模型，因为它易于操作且大小合适。这种大小允许进行腹腔镜研究，旨在实时跟踪植入腹膜界面的生物材料的行为，腹膜界面是一个脆弱的界面，在人类实践中经常导致并发症。兔子的大小还提供了足够数量的植入物样本，以便在植入后几个时间点进行完整的一系列测试。在本综述中，我们首先描述了建立的模型，然后提供了迄今为止使用这些模型测试不同类型生物材料所获得的结果。我们以讨论这些结果的临床意义结束了综述。
