Colorado Center for Reproductive Medicine, Englewood, CO, USA.
Instituto Valenciano de Infertilidad (IVI) Valencia, INCLIVA-Universidad de Valencia, Valencia, Spain.
Reprod Biomed Online. 2017 Oct;35(4):391-399. doi: 10.1016/j.rbmo.2017.06.023. Epub 2017 Jul 14.
Infertility affects over 70 million couples globally. Access to, and interest in, assisted reproductive technologies is growing worldwide, with more couples seeking medical intervention to conceive, in particular by IVF. Despite numerous advances in IVF techniques since its first success in 1978, almost half of the patients treated remain childless. The multifactorial nature of IVF treatment means that success is dependent on many variables. Therefore, it is important to examine how each variable can be optimized to achieve the best possible outcomes for patients. The current approach to IVF is fragmented, with various protocols in use. A systematic approach to establishing optimum best practices may improve IVF success and live birth rates. Our vision of the future is that technological advancements in the laboratory setting are standardized and universally adopted to enable a gold standard of care. Implementation of best practices for laboratory procedures will enable clinicians to generate high-quality gametes, and to produce and identify gametes and embryos of maximum viability and implantation potential, which should contribute to improving take-home healthy baby rates.
不孕症影响着全球超过 7000 万对夫妇。全球范围内，人们对辅助生殖技术的关注度和可及性都在不断提高，越来越多的夫妇寻求医疗干预来怀孕，特别是通过体外受精（IVF）。尽管自 1978 年首次成功以来，IVF 技术取得了许多进展，但仍有近一半接受治疗的患者无法生育。IVF 治疗的多因素性质意味着成功取决于许多变量。因此，检查如何优化每个变量以实现患者的最佳结果非常重要。目前的 IVF 方法是碎片化的，有各种不同的方案在使用。系统地确定最佳实践可能会提高 IVF 的成功率和活产率。我们对未来的设想是，实验室环境中的技术进步得到标准化和普遍采用，以实现护理的金标准。实施实验室程序的最佳实践将使临床医生能够生成高质量的配子，并生产和识别具有最大活力和植入潜力的配子和胚胎，这应该有助于提高携带健康婴儿回家的比例。
