Faculty of Dental Medicine, University of Porto, Porto, Portugal.
REQUIMTE, and Department of Metallurgical Engineering and Materials, Faculty of Engineering, University of Porto, Porto, Portugal; CENIMAT/i3N, Department of Materials Science, Nova University of Lisbon, Lisbon, Portugal.
J Endod. 2017 Sep;43(9):1505-1510. doi: 10.1016/j.joen.2017.03.015. Epub 2017 Jul 27.
The purpose of this study was to evaluate the use of solvents that are not traditionally used in dentistry for the dissolution of an epoxy resin-based sealer and the effect of ultrasonic agitation (UA).
The dissolution of the AH Plus sealer (Dentsply DeTrey, Konstanz, Germany) and the effect of UA in various solvents (eucalyptol, xylene, chloroform, EndoSolv R [Septodont, Cedex, France], EndoSolv E [Septodont], methyl ethyl ketone [MEK], and ethyl acetate) were quantified. The dissolving capacity was assessed by weight loss, Vicker microhardness, scanning electron microscopy (SEM), and X-ray diffraction (XRD). The results were compared with factorial analysis of variance using IBM SPSS Statistics 23.0 software (IBM, Armonk, NY), considering a 0.05 significance level. A preliminary ex vivo study was performed in extracted teeth, with MEK activated by UA as the final irrigation after mechanical removal of the filling material. SEM was used for assessing the cleanliness of the root canal walls.
The new solvent proposals, ethyl acetate and MEK, exhibited high dissolution ability, almost reaching chloroform. UA increased dissolution. Vicker values corroborated the dissolution assays. SEM and XRD revealed that solvents affected mainly the organic component of the sealer. Ex vivo results confirmed the immersion model findings.
MEK and ethyl acetate proved to be excellent alternatives to chloroform or xylene solvents. MEK presented a high sealer dissolving ability in a short period, especially with UA, without the potential hazards of chloroform, suggesting it is a good approach to AH Plus sealer's dissolution empowered by UA. These results should encourage further studies in order to confirm their clinical relevance.
本研究旨在评估非传统牙科用溶剂在溶解环氧树脂基封口剂中的应用，以及超声搅拌（UA）的效果。
评估 AH Plus 封口剂（Dentsply DeTrey，德国康斯坦茨）的溶解情况，以及在不同溶剂（桉树油、二甲苯、氯仿、EndoSolv R[Septodont，Cedex，法国]、EndoSolv E[Septodont]、甲乙酮[MEK]和乙酸乙酯）中的 UA 效果。通过重量损失、维氏硬度、扫描电子显微镜（SEM）和 X 射线衍射（XRD）评估溶解能力。使用 IBM SPSS Statistics 23.0 软件（IBM，Armonk，NY）进行方差分析，结果以 0.05 为显著性水平。在离体牙中进行了初步研究，在机械去除填充物后，用 MEK 激活 UA 作为最后的冲洗液。SEM 用于评估根管壁的清洁度。
新的溶剂提议，乙酸乙酯和 MEK，表现出高溶解能力，几乎达到氯仿的水平。UA 增加了溶解。维氏硬度值证实了溶解试验。SEM 和 XRD 显示，溶剂主要影响封口剂的有机成分。离体研究结果证实了浸没法的发现。
MEK 和乙酸乙酯被证明是氯仿或二甲苯溶剂的极好替代品。MEK 尤其在 UA 作用下，在短时间内对封口剂有很强的溶解能力，而没有氯仿的潜在危险，表明在 UA 作用下，MEK 是一种很好的溶解 AH Plus 封口剂的方法。这些结果应鼓励进一步研究，以确认其临床相关性。
