Koh Young Wha, Lee Su Jin, Park Seong Yong
Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea.
Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, Republic of Korea.
Pathol Res Pract. 2017 Sep;213(9):1134-1138. doi: 10.1016/j.prp.2017.07.006. Epub 2017 Jul 6.
Lactate dehydrogenase B (LDHB) expression and the level of serum LDH were involved in tumor progression. Correlations between these parameters and their prognostic significance were not assessed in non-small cell lung cancer (NSCLC). We evaluated LDHB expression by immunohistochemical method and serum LDH in 243 NSCLC patients treated with surgical resection [136 adenocarcinomas (ADCs), 89 squamous cell carcinomas (SqCCs) and 18 other type carcinomas]. Correlation between LDHB expression and serum LDH was assessed, and the prognostic significance was determined. LDHB expression was identified in 52% of SqCC and 55% of ADC tissue samples. LDHB-positive SqCC patients had a higher recurrence-free survival (RFS) rate than LDHB-negative patients (p=0.017). LDHB-positive and LDHB-negative patients showed similar RFS rates in ADCs (p=0.519). Multivariate analysis showed that LDHB expression was an independent risk factor in lung SqCCs (hazard ratio=0.393, p=0.028). A positive correlation was found between LDHB expression and serum LDH level (p=0.02). High LDHB expression is significantly associated with the level of serum LDH and better clinical outcomes in lung SqCC.
乳酸脱氢酶B（LDHB）的表达及血清乳酸脱氢酶水平与肿瘤进展有关。在非小细胞肺癌（NSCLC）中，未评估这些参数之间的相关性及其预后意义。我们采用免疫组化方法评估了243例接受手术切除的NSCLC患者（136例腺癌、89例鳞状细胞癌和18例其他类型癌）的LDHB表达及血清乳酸脱氢酶水平。评估了LDHB表达与血清乳酸脱氢酶之间的相关性，并确定了其预后意义。在52%的鳞状细胞癌和55%的腺癌组织样本中检测到LDHB表达。LDHB阳性的鳞状细胞癌患者的无复发生存（RFS）率高于LDHB阴性患者（p=0.017）。在腺癌中，LDHB阳性和阴性患者的RFS率相似（p=0.519）。多因素分析显示，LDHB表达是肺鳞状细胞癌的独立危险因素（风险比=0.393，p=0.028）。发现LDHB表达与血清乳酸脱氢酶水平呈正相关（p=0.02）。高LDHB表达与血清乳酸脱氢酶水平及肺鳞状细胞癌更好的临床结局显著相关。
