Park Soo Hyun, Russ Brian E, McMahon David B T, Koyano Kenji W, Berman Rebecca A, Leopold David A
Section on Cognitive Neurophysiology and Imaging, National Institute of Mental Health, 49 Convent Dr., Bethesda, MD 20892, USA; Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
Section on Cognitive Neurophysiology and Imaging, National Institute of Mental Health, 49 Convent Dr., Bethesda, MD 20892, USA.
Neuron. 2017 Aug 16;95(4):971-981.e5. doi: 10.1016/j.neuron.2017.07.014. Epub 2017 Jul 27.
Neurons within fMRI-defined face patches of the macaque brain exhibit shared categorical responses to flashed images but diverge in their responses under more natural viewing conditions. Here we investigate functional diversity among neurons in the anterior fundus (AF) face patch, combining whole-brain fMRI with longitudinal single-unit recordings in a local population (<1 mm). For each cell, we computed a whole-brain correlation map based on its shared time course with voxels throughout the brain during naturalistic movie viewing. Based on this mapping, neighboring neurons showed markedly different affiliation with distant visually responsive areas and fell coarsely into subpopulations. Of these, only one subpopulation (∼16% of neurons) yielded similar correlation maps to the local fMRI signal. The results employ the readout of large-scale fMRI networks and, by indicating multiple functional domains within a single voxel, present a new view of functional diversity within a local neural population.
猕猴大脑功能磁共振成像（fMRI）定义的面部区域内的神经元，对闪烁图像表现出共同的分类反应，但在更自然的观看条件下其反应存在差异。在这里，我们结合全脑功能磁共振成像和对局部群体（<1毫米）进行纵向单神经元记录，研究了眼底前部（AF）面部区域神经元之间的功能多样性。对于每个细胞，我们在自然主义电影观看期间，根据其与全脑体素的共享时间进程计算了一个全脑相关图。基于这种映射，相邻神经元与远处视觉反应区域的关联明显不同，并大致分为亚群。其中，只有一个亚群（约占神经元的16%）产生了与局部功能磁共振成像信号相似的相关图。这些结果利用了大规模功能磁共振成像网络的读出，并通过在单个体素内指示多个功能域，呈现了局部神经群体内功能多样性的新观点。
