Zhou Xin, Li Wei-yun, Wang Hong-yan
CAS Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.
Yi Chuan. 2017 Jul 20;39(7):642-649. doi: 10.16288/j.yczz.17-066.
The Hippo signaling pathway regulates cell proliferation, organ size and tissue regeneration through a series of kinase cascades. MST1/2 is the mammalian orthologue of the core kinase Hippo, which is crucial for the activation of downstream signaling. Additionally, MST1/2 has been reported to play important roles in cell differentiation, morphology and cytoskeleton reorganization. Recent evidence suggests that MST1/2 is involved in the regulation of T cell adhesion, migration, homing and Treg cell maturation and functions. Interestingly, these processes are not dependent on the canonical, but a non-canonical Hippo signaling pathway. More recent studies have revealed that MST1/2 mediates the innate immune response against pathogens or viruses, especially on macrophage phagocytosis as well as cytokines and ROS production. MST1/2 is associated with various diseases, such as bacterial or viral infection, inflammation-related cancer, and atherosclerosis. In this review, we summarize recent findings on the functions of MST1/2 in the innate immune response and inflammation-related diseases.
河马信号通路通过一系列激酶级联反应调节细胞增殖、器官大小和组织再生。MST1/2是核心激酶河马在哺乳动物中的同源物，对下游信号的激活至关重要。此外，据报道MST1/2在细胞分化、形态和细胞骨架重组中发挥重要作用。最近的证据表明，MST1/2参与调节T细胞粘附、迁移、归巢以及调节性T细胞的成熟和功能。有趣的是，这些过程不依赖于经典的，而是非经典的河马信号通路。最近的研究表明，MST1/2介导针对病原体或病毒的先天免疫反应，特别是在巨噬细胞吞噬以及细胞因子和活性氧产生方面。MST1/2与多种疾病相关，如细菌或病毒感染、炎症相关癌症和动脉粥样硬化。在这篇综述中，我们总结了关于MST1/2在先天免疫反应和炎症相关疾病中的功能的最新发现。
