Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.
Cell Adh Migr. 2023 Dec;17(1):1-15. doi: 10.1080/19336918.2023.2276616. Epub 2023 Nov 1.
The mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity.
哺乳动物无活性丝氨酸/苏氨酸激酶 1/2（MST1/2）属于丝氨酸/苏氨酸（GC）蛋白激酶超家族。大量研究证实 MST1/2 在炎症和免疫中起着至关重要的作用。MST1/2 与炎症的进展密切相关。通常情况下，MST1/2 通过 MST1-JNK、MST1-mROS、MST1-Foxo3 和 NF-κB 途径以及肿瘤坏死因子-α（TNF-α）、线粒体延伸因子 1（MIEF1）和脂多糖（LPS）等几种调节因子加重炎症损伤。此外，MST1/2 还参与免疫调节，通过调节 MST1/2-Rac、MST1-Akt1/c-myc、MST1-Foxos、MST1-STAT、Btk 途径和淋巴细胞功能相关抗原 1（LFA-1）来平衡免疫激活和耐受，从而防止免疫缺陷综合征和自身免疫性疾病。本文综述了 MST1/2 对炎症和免疫的影响。
