Department of Microbiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol. 2018 Feb 5;9:149. doi: 10.3389/fimmu.2018.00149. eCollection 2018.
The Hippo pathway is an evolutionarily conserved pathway crucial for regulating tissue size and for limiting cancer development. However, recent work has also uncovered key roles for the mammalian Hippo kinases, Mst1/2, in driving appropriate immune responses by directing T cell migration, morphology, survival, differentiation, and activation. In this review, we discuss the classical signaling pathways orchestrated by the Hippo signaling pathway, and describe how Mst1/2 direct T cell function by mechanisms not seeming to involve the classical Hippo pathway. We also discuss why Mst1/2 might have different functions within organ systems and the immune system. Overall, understanding how Mst1/2 transmit signals to discrete biological processes in different cell types might allow for the development of better drug therapies for the treatments of cancers and immune-related diseases.
Hippo 通路是一条进化上保守的通路，对于调节组织大小和限制癌症发展至关重要。然而，最近的研究还揭示了哺乳动物 Hippo 激酶 MST1/2 的关键作用，通过指导 T 细胞迁移、形态、存活、分化和激活，来驱动适当的免疫反应。在这篇综述中，我们讨论了 Hippo 信号通路协调的经典信号通路，并描述了 MST1/2 如何通过似乎不涉及经典 Hippo 通路的机制来指导 T 细胞功能。我们还讨论了为什么 MST1/2 在不同的器官系统和免疫系统中可能具有不同的功能。总的来说，了解 MST1/2 如何将信号传递到不同细胞类型中的离散生物学过程，可能有助于开发更好的药物疗法，用于治疗癌症和与免疫相关的疾病。
