携带BoLA II类DRB3*0902等位基因的牛，其牛白血病前病毒载量显著较低。
Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads.
作者信息
Hayashi Takumi, Mekata Hirohisa, Sekiguchi Satoshi, Kirino Yumi, Mitoma Shuya, Honkawa Kazuyuki, Horii Yoichiro, Norimine Junzo
机构信息
Laboratory of Animal Infectious Disease and Prevention, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai-Nishi, Miyazaki 889-2192, Japan.
Organization for Promotion of Tenure Track, University of Miyazaki, 1-1 Gakuen-Kibanadai-Nishi, Miyazaki 889-2192, Japan.
出版信息
J Vet Med Sci. 2017 Sep 12;79(9):1552-1555. doi: 10.1292/jvms.16-0601. Epub 2017 Jul 28.
The bovine MHC (BoLA) class II DRB3 alleles are associated with polyclonal expansion of lymphocytes caused by bovine leukemia virus (BLV) infection in cattle. To examine whether the DRB30902 allele, one of the resistance-associated alleles, is associated with the proviral load, we measured BLV proviral load of BLV-infected cattle and clarified their DRB3 alleles. Fifty-seven animals with DRB30902 were identified out of 835 BLV-infected cattle and had significantly lower proviral load (P<0.000001) compared with the rest of the infected animals, in both Japanese Black and Holstein cattle. This result strongly indicates that the BoLA class II DRA/DRB3*0902 molecule plays an important immunological role in suppressing viral replication, resulting in resistance to the disease progression.
牛主要组织相容性复合体（BoLA）Ⅱ类DRB3等位基因与牛白血病病毒（BLV）感染引起的牛淋巴细胞多克隆扩增有关。为了研究抗性相关等位基因之一的DRB30902等位基因是否与前病毒载量相关，我们测量了BLV感染牛的BLV前病毒载量，并明确了它们的DRB3等位基因。在835头BLV感染牛中，鉴定出57头携带DRB30902的牛，在日本黑牛和荷斯坦牛中，这些牛的前病毒载量均显著低于其他感染动物（P<0.000001）。这一结果有力地表明，BoLAⅡ类DRA/DRB3*0902分子在抑制病毒复制中发挥重要免疫作用，从而导致对疾病进展的抗性。
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