Shah Vikas N, Chagot Benjamin, Chazin Walter J
Departments of Biochemistry, Chemistry and Physics; Vanderbilt University Medical Center; Nashville, Tennessee USA.
Calcium Bind Proteins. 2006 Oct-Dec;1(4):203-212.
Calcium plays an important role in regulating hundreds of biological processes due to its primary role as one of the most ubiquitous second messengers. As a result, the levels of calcium are tightly regulated as are the peak and trough calcium concentrations during a calcium signal. Calcium levels are controlled via a variety of feedback mechanisms and exchangers/transporters. Here the role of calcium in the feedback regulation of ion channel function is reviewed, with an emphasis on the molecular mechanisms governing calcium-dependent function. In particular, the role of calcium in the regulation of voltage-gated sodium, calcium, and potassium channels are reviewed as well as its effects on the ryanodine receptor.
钙作为最普遍存在的第二信使之一,在调节数百种生物过程中发挥着重要作用。因此,钙的水平受到严格调控,钙信号期间的钙浓度峰值和谷值也是如此。钙水平通过多种反馈机制以及交换器/转运体进行控制。本文综述了钙在离子通道功能反馈调节中的作用,重点关注调控钙依赖性功能的分子机制。特别地,还综述了钙在电压门控钠通道、钙通道和钾通道调节中的作用及其对兰尼碱受体的影响。