Kang Dong Hee, Kim Su Young, Kim Hyuck Goo, Park Jung Hyun, Kim Tae Kyun, Kim Kyung Hoon
Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
Korean J Pain. 2017 Jul;30(3):214-219. doi: 10.3344/kjp.2017.30.3.214. Epub 2017 Jun 30.
As herpes zoster progresses via postherpetic neuralgia (PHN) to well-established PHN, it presents its recalcitrant nature to the treatment. At this point, the well-established PHN is fixed as a non-treatable, but manageable chronic painful neuropathic disorder. This study evaluated the incidence of complete relief from PHN according to PHN duration at their first visit, and the other factors influencing it.
A retrospective chart review was performed on patients with PHN at a university-based pain clinic over 7 years. The responders were defined as patients who had complete relief from pain after 1 year of active treatment. Age, sex, PHN duration at their first visit, dermatomal distribution, and underlying disorders were compared in the responder and non-responder groups. Responders were also compared according to these factors.
Among 117 PHN patients (M/F = 48/69), 35 patients (29.9%) had complete relief from PHN. Mean ages were 64.3 ± 10.6 and 66.9 ± 10.7 years, numbers of male to female patients were 11/24 and 37/45, and mean durations of PHN at their first visit were 8.5 ± 6.3 and 15.3 ± 10.7 months in the responder and non- responder groups, respectively. In addition, PHN patients who visited the clinic before 9 months showed a better result. Dermatomal distribution and underlying disorders did not show significant differences.
Almost 30% of PHN patients received complete relief. Those who sought treatment in a pain clinic before 9 months received a better result.
随着带状疱疹经由疱疹后神经痛（PHN）发展为确诊的PHN，它呈现出对治疗的顽固性。此时，确诊的PHN被认定为一种不可治愈但可控制的慢性疼痛性神经病变。本研究根据首次就诊时PHN的病程评估了PHN完全缓解的发生率以及其他影响因素。
对一所大学疼痛诊所7年间的PHN患者进行回顾性病历审查。缓解者定义为经过1年积极治疗后疼痛完全缓解的患者。比较缓解组和未缓解组患者的年龄、性别、首次就诊时的PHN病程、皮节分布和基础疾病。还根据这些因素对缓解者进行了比较。
在117例PHN患者（男/女 = 48/69）中，35例患者（29.9%）的PHN完全缓解。缓解组和未缓解组的平均年龄分别为64.3±10.6岁和66.9±10.7岁，男性患者与女性患者人数分别为11/24和37/45，首次就诊时PHN的平均病程分别为8.5±6.3个月和15.3±10.7个月。此外，在9个月前到诊所就诊的PHN患者效果更好。皮节分布和基础疾病没有显著差异。
近30%的PHN患者实现了完全缓解。那些在9个月前到疼痛诊所寻求治疗的患者效果更好。
