Agaba Patricia, Meloni Seema, Sule Halima, Ocheke Amaka, Agaba Emmanuel, Idoko John, Kanki Phyllis
Department of Family Medicine, University of Jos/Jos University Teaching Hospital, Nigeria.
APIN Centre, Jos University Teaching Hospital, Jos, Nigeria.
J Virus Erad. 2017 Jul 1;3(3):145-151. doi: 10.1016/S2055-6640(20)30333-2.
Effective antiretroviral therapy has prolonged the survival of patients with HIV. Accordingly, studies of the consequences of ageing are increasingly important. We determined the prevalence of early menopause (EM) and its associated factors in a cohort of HIV-infected and HIV-negative controls in Jos, Nigeria.
HIV-infected women accessing care in an ambulatory setting and their negative counterparts from the general population were included. Menopause was defined as having gone one year since the last menstrual period. EM was defined as the onset of menopause at ≤45 years of age. Baseline characteristics were compared and logistic regression analyses were used to determine factors independently associated with EM.
Out of a total of 253 women included, 58 attained menopause early, giving an EM prevalence of 22.9% (95% confidence interval [CI] 17.9-28.6%). Women with EM were younger (<0.001) and had been infected with HIV for a shorter period (=0.007). Baseline CD4+ cell count (=0.66) and viral load (=0.15) were similar among those with and without EM. For all subjects, HIV infection (adjusted odds ratio [AOR}=10.95, 95% CI 1.39-86.33) and sexual activity (AOR=2.37, 95% CI 1.24-4.52) were associated with EM while early menarche (AOR=14.88, 95% CI 1.37-161.10) and sexual activity (AOR=2.02, 95% CI 1.03-3.96) were independently associated with EM.
Over a quarter of our postmenopausal women attained menopause early. No HIV-related factor predicted EM in this study. A better understanding of ageing in these women is important to determine a more appropriate disease-management approach during this period of life.
有效的抗逆转录病毒疗法延长了HIV患者的生存期。因此，对衰老后果的研究变得越来越重要。我们在尼日利亚乔斯的一组HIV感染患者和HIV阴性对照人群中，确定了早期绝经（EM）的患病率及其相关因素。
纳入在门诊接受治疗的HIV感染女性及其来自普通人群的HIV阴性对照者。绝经定义为自最后一次月经来潮已过去一年。早期绝经定义为在45岁及以下出现绝经。比较基线特征，并采用逻辑回归分析确定与早期绝经独立相关的因素。
在纳入的253名女性中，58人过早绝经，早期绝经患病率为22.9%（95%置信区间[CI]17.9 - 28.6%）。早期绝经的女性更年轻（<0.001），感染HIV的时间更短（=0.007）。有或没有早期绝经的女性，其基线CD4 +细胞计数（=0.66）和病毒载量（=0.15）相似。对于所有受试者，HIV感染（调整优势比[AOR]=10.95，95%CI 1.39 - 86.33）和性活动（AOR=2.37，95%CI 1.24 - 4.52）与早期绝经相关，而初潮早（AOR=14.88，95%CI 1.37 - 161.10）和性活动（AOR=2.02，95%CI 1.03 - 3.96）独立与早期绝经相关。
我们超过四分之一的绝经后女性过早绝经。本研究中没有HIV相关因素可预测早期绝经。更好地了解这些女性的衰老情况对于在此生命阶段确定更合适的疾病管理方法很重要。
