Xiao Ting, Chen Li-Ping, Liu Hui, Xie SiSi, Luo Yan, Wu Ding-Chang
Department of Clinical Laboratory, Fujian Longyan First Hospital, Longyan First Affiliated Hospital, Fujian Medical University, Longyan, Fujian 364000, China.
Department of Neonatal Unit, Fujian Longyan First Hospital, Longyan First Affiliated Hospital, Fujian Medical University, Longyan, Fujian 364000, China.
Biomed Res Int. 2017;2017:8617076. doi: 10.1155/2017/8617076. Epub 2017 Jul 3.
This study aimed to investigate the etiology and risk factors of neonatal sepsis. A retrospective analysis was conducted on 192 patients with sepsis from August 2013 to March 2015. One hundred and six healthy neonates were used as the control group. Logistic regression was used to analyze the risk factors and ROC curve analysis performed in laboratory which indicated a significant correlation. The results of univariate analysis showed that postnatal age, body weight, and parity were significantly related to neonatal sepsis ( < 0.5). Logistic regression analysis demonstrated that postnatal age and parity are independent risk factors for neonatal sepsis (OR were 1.176 and 0.692, resp., < 0.001). The maximum area underneath the curve (ROC) of soluble CD14 (sCD14-ST), which was the most indicative biomarker of sepsis diagnostically, was 0.953 with sensitivity and specificity of 93.8% and 84.9%, respectively. and were the main bacterial strains causing neonatal sepsis, while postnatal age was an independent risk factor for the onset of disease. sCD14-ST could be a potential useful diagnostic marker for pediatric sepsis.
本研究旨在探讨新生儿败血症的病因及危险因素。对2013年8月至2015年3月期间192例败血症患者进行回顾性分析。选取106例健康新生儿作为对照组。采用逻辑回归分析危险因素，并在实验室进行ROC曲线分析，结果显示存在显著相关性。单因素分析结果表明，出生后年龄、体重和胎次与新生儿败血症显著相关（P<0.5）。逻辑回归分析表明，出生后年龄和胎次是新生儿败血症的独立危险因素（OR分别为1.176和0.692，P<0.001）。可溶性CD14（sCD14-ST）是败血症诊断中最具指示性的生物标志物，其曲线下最大面积（ROC）为0.953，敏感性和特异性分别为93.8%和84.9%。肺炎克雷伯菌和大肠埃希菌是导致新生儿败血症的主要菌株，而出生后年龄是疾病发生的独立危险因素。sCD14-ST可能是小儿败血症潜在的有用诊断标志物。
